Effect of nicotine and alpha‐7 nicotinic modulators on visceral pain‐induced conditioned place aversion in mice
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pain"
DOI: 10.1002/ejp.1231
Abstract: Preclinical assays of affective and sensorial aspects of nociception play a key role in research on both the neurobiology of pain and the development of novel analgesics. Therefore, we investigated the effects of nicotine and… read more here.
Keywords: nicotine alpha; effect nicotine; visceral pain; alpha nicotinic ... See more keywords
[From gut feeling to visceral pain : Effects of negative expectations in the context of the gut-brain axis].
Sign Up to like & getrecommendations! Published in 2021 at "Schmerz"
DOI: 10.1007/s00482-021-00614-w
Abstract: Disturbances of the gut-brain axis are characterized by complex dysfunctions on peripheral and central nervous system levels, which can contribute to visceral hypervigilance and hyperalgesia and imprint visceral pain. Numerous cognitive, emotional and psychoneurobiological factors… read more here.
Keywords: gut brain; visceral pain; brain axis; pain ... See more keywords
Receptors involved in dexketoprofen analgesia in murine visceral pain
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biosciences"
DOI: 10.1007/s12038-020-00064-z
Abstract: Various animal models, especially rodents, are used to study pain, due to the difficulty of studying it in humans. Many drugs that produce analgesia have been studied and there is evidence among which NSAIDs deserve… read more here.
Keywords: dex; involved dexketoprofen; visceral pain; dexketoprofen analgesia ... See more keywords
Impaired visceral pain-related functions of the midbrain periaqueductal gray in rats with colitis
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2022.02.002
Abstract: The midbrain periaqueductal gray (PAG) is a key structure involved in the supraspinal modulation of pain. Previous studies have reported the association of gut inflammation-triggered chronic abdominal pain with structural and neuronal alterations within the… read more here.
Keywords: visceral pain; midbrain periaqueductal; periaqueductal gray; pain ... See more keywords
A novel visceral pain model of uterine cervix inflammation in rat.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174080
Abstract: Treatment of visceral pain originating from the uterine cervix is a substantial clinical problem. The underlying mechanisms of such visceral pain remain unclear mainly due to a lack of reliable model. This study aimed to… read more here.
Keywords: visceral pain; cervix inflammation; model; uterine cervix ... See more keywords
Estrous cycle and ovariectomy-induced changes in visceral pain are microbiota-dependent
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102850
Abstract: Summary Visceral hypersensitivity (VH) is a hallmark of many functional gastrointestinal disorders including irritable bowel syndrome and is categorized by a dull, diffuse sensation of abdominal pain. Recently, the gut microbiota has been implicated in… read more here.
Keywords: ovariectomy; visceral pain; estrous cycle; germ free ... See more keywords
Rhamnogalacturonan polysaccharide inhibits inflammation and oxidative stress and alleviates visceral pain
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2021.104483
Abstract: Abstract Rhamnogalacturonan (RGal) is a polysaccharide isolated from Acmella oleracea that ameliorates the intestinal barrier in an ulcerative colitis model induced by dextran sulfate sodium (DSS) and in Caco-2 cells. Here we investigate if RGal… read more here.
Keywords: oxidative stress; pain; visceral pain; inflammation oxidative ... See more keywords
Selective corticotropin-releasing factor 1 receptor antagonist E2508 reduces restraint stress-induced defecation and visceral pain in rat models
Sign Up to like & getrecommendations! Published in 2017 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2016.10.025
Abstract: N-Cyclopropylmethyl-7-(2,6-dimethoxy-4-methoxymethylphenyl)-2-ethyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[1,5-a]pyridin-3-amine tosylate (E2508) is a newly discovered selective corticotropin-releasing factor 1 receptor antagonist. Here, we investigated the effects of E2508 on wrap restraint stress-induced defecation and visceral pain in rats. Oral pretreatment with E2508 dose-dependently… read more here.
Keywords: receptor antagonist; restraint stress; visceral pain;
Looking at visceral pain: New vistas
Sign Up to like & getrecommendations! Published in 2018 at "Scandinavian Journal of Pain"
DOI: 10.1016/j.sjpain.2011.05.002
Abstract: The usefulness of visceral pain is not immediately apparent. herrington defined pain as the psychical adjunct of a protective eflex, implying that pain has a protective and useful role. But what s the usefulness of… read more here.
Keywords: new vistas; visceral pain; looking visceral; brain ... See more keywords
Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00515
Abstract: The soluble epoxide hydrolase (sEH) has been suggested as a pharmacological target for the treatment of several diseases, including pain-related disorders. Herein, we report further medicinal chemistry around new benzohomoadamantane-based sEH inhibitors (sEHI) in order… read more here.
Keywords: soluble epoxide; epoxide hydrolase; chemistry; benzohomoadamantane based ... See more keywords
Painful neurotrophins and their role in visceral pain
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000386
Abstract: Beyond their well-known role in embryonic development of the central and peripheral nervous system, neurotrophins, particularly nerve growth factor and brain-derived neurotrophic factor, exert an essential role in pain production and sensitization. This has mainly… read more here.
Keywords: bowel; painful neurotrophins; visceral pain; role ... See more keywords