Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.03.037
Abstract: ABSTRACT Stress‐induced altered visceral sensation and impaired gut barrier play an important role in the pathophysiology of irritable bowel syndrome (IBS). These responses were demonstrated to be peripheral corticotropin‐releasing factor (CRF) dependent and also mediated… read more here.
Keywords: gut barrier; stress induced; model; antagonist ... See more keywords
Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2021.04.005
Abstract: Short chain fatty acids readily crosses the gut-blood and blood-brain barrier and acts centrally to influence neuronal signaling. We hypothesized that butyrate, a short-chain fatty acid produced by bacterial fermentation, in the central nervous system… read more here.
Keywords: barrier; butyrate; septic lethality; visceral sensation ... See more keywords