Improving Viscosity and Stability of a Highly Concentrated Monoclonal Antibody Solution with Concentrated Proline
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DOI: 10.1007/s11095-018-2398-1
Abstract: PurposeTo explain the effects of the osmolyte proline on the protein-protein interactions (PPI), viscosity and stability of highly concentrated antibody solutions in contrast to other neutral osmolytes.MethodsThe viscosity of ~225 mg/mL mAb solutions was measured with… read more here.
Keywords: viscosity; stability highly; highly concentrated; viscosity stability ... See more keywords