Prognostic significance and therapeutic potential of the immune checkpoint VISTA in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03463-9
Abstract: Objective V-domain Ig suppressor of T cell activation (VISTA) is a novel immune checkpoint protein that belongs to the B7 family. The aim of this study was to investigate the prognostic significance and therapeutic potential… read more here.
Keywords: immune checkpoint; significance therapeutic; cancer; vista ... See more keywords
A small molecule inhibitor of VSIG-8 prevents its binding to VISTA
Sign Up to like & getrecommendations! Published in 2022 at "Investigational New Drugs"
DOI: 10.1007/s10637-022-01244-4
Abstract: The V-region immunoglobulin-containing suppressor of T cell activation (VISTA), a unique B7 family member, is an attractive immunotherapeutic target for cancer, autoimmune and inflammatory diseases. In 2016, a patent demonstrated V-Set and Immunoglobulin domain containing… read more here.
Keywords: vsig; small molecule; inhibitor vsig; vista ... See more keywords
Inhibition of allogeneic islet graft rejection by VISTA-conjugated liposome.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.188
Abstract: The Ig superfamily member V-domain Ig-containing suppressor of T-cell activation (VISTA) is a negative regulator with broad-spectrum activities and has reported that blockade of VISTA or combination with other negative checkpoint receptors sufficiently break tumor… read more here.
Keywords: vista conjugated; conjugated liposome; islet; rejection ... See more keywords
3D isotropic T2-weighted fast spin echo (VISTA) versus 2D T2-weighted fast spin echo in evaluation of the calcaneofibular ligament in the oblique coronal plane.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical radiology"
DOI: 10.1016/j.crad.2016.09.023
Abstract: AIM To investigate whether the image quality of three-dimensional (3D) volume isotropic fast spin echo acquisition (VISTA) magnetic resonance imaging (MRI) of the calcaneofibular ligament (CFL) view is comparable to that of 2D fast spin… read more here.
Keywords: fast spin; weighted fast; cfl; spin echo ... See more keywords
Analysis of the immune checkpoint V-domain Ig-containing suppressor of T-cell activation (VISTA) in endometrial cancer
Sign Up to like & getrecommendations! Published in 2021 at "Modern Pathology"
DOI: 10.1038/s41379-021-00901-y
Abstract: V-domain Ig-containing suppressor of T-cell activation (VISTA) is a novel immune checkpoint protein and a potential immunotherapeutic target. However, its expression in endometrial cancer has not been clearly defined. This study aimed to investigate VISTA… read more here.
Keywords: cd8; endometrial cancer; vista; cell ... See more keywords
An engineered antibody binds a distinct epitope and is a potent inhibitor of murine and human VISTA
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71519-4
Abstract: V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint that maintains peripheral T cell quiescence and inhibits anti-tumor immune responses. VISTA functions by dampening the interaction between myeloid cells and T… read more here.
Keywords: antibody; binds distinct; distinct epitope; vista ... See more keywords
182 Highly potent fully human anti-VISTA antibodies – a new target checkpoint inhibitor against immunosuppressive myeloid cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0182
Abstract: Background V-domain Immunoglobulin Suppressor of T cell Activation (VISTA/PD-1H) is a B7 family ligand expressed on circulating and intratumoural myeloid cells as well as Treg and NK cells. It has been shown to inhibit T… read more here.
Keywords: myeloid cells; anti; vista antibodies; anti vista ... See more keywords
Rationally targeted anti-VISTA antibody that blockades the C-C’ loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003382
Abstract: Background Despite significant progress in cancer immunotherapy in recent years, resistance to existing immune checkpoint therapies (ICT) is common. V-domain Ig suppressor of T cell activation (VISTA), a predominantly myeloid immune checkpoint regulator, represents a… read more here.
Keywords: anti vista; hmbd 002; vista; vista antibody ... See more keywords
Abstract 972: VISTA expression in patients with advanced solid tumors: A potential biomarker in VISTA-101 clinical trial
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-972
Abstract: V-domain Immunoglobulin Suppressor of T cell Activation (VISTA/PD-1H) is a B7 family member highly expressed on circulating and intra-tumoral myeloid cells. It is a negative checkpoint inhibitor that inhibits anti-tumor T cell response. In patients,… read more here.
Keywords: expression; clinical trial; vista; tumor ... See more keywords
Hypoxia-Induced VISTA Promotes the Suppressive Function of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-18-0507
Abstract: VISTA, induced on MDSCs by hypoxia in the tumor microenvironment, enhances suppression of both CD4+ and CD8+ T cells. This mechanism of hypoxia-driven immune escape and checkpoint resistance suggests a translatable approach to combination therapies.… read more here.
Keywords: hypoxia; tumor microenvironment; vista; suppressor ... See more keywords
VISTA targeting of T-cell quiescence and myeloid suppression overcomes adaptive resistance.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0116
Abstract: VISTA is a premier target for cancer treatment due to its broad expression in many cancer types and enhanced expression upon development of adaptive immune checkpoint resistance. In the CT26 colorectal cancer model, monotherapy of… read more here.
Keywords: cell; adaptive resistance; quiescence; anti vista ... See more keywords