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Published in 2018 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2018.1448060
Abstract: ABSTRACT Introduction: Pharmacotherapy with visual cycle modulators (VCMs) is under investigation for retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardt macular dystrophy (SMD) and nonexudative age-related macular degeneration (AMD), all blinding diseases that lack effective…
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Keywords:
vcms;
pharmacotherapy retinal;
retinal disease;
visual cycle ... See more keywords
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Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16569
Abstract: Ageing presents adverse effects on the retina and is the primary risk factor for age‐related macular degeneration (AMD). We report the first RNA‐seq analysis of age‐related transcriptional changes in the human retinal pigment epithelium (RPE),…
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Keywords:
transcription;
seq analysis;
human retinal;
cycle ... See more keywords
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Published in 2022 at "Biomedical optics express"
DOI: 10.1364/boe.455783
Abstract: Photoreceptors are the key functional cell types responsible for the initiation of vision in the retina. Phototransduction involves isomerization and conversion of vitamin A compounds, known as retinoids, and their recycling through the visual cycle.…
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Keywords:
autofluorescence lifetime;
visual cycle;
situ autofluorescence;
retinal organoids ... See more keywords