Pharmacotherapy of retinal disease with visual cycle modulators
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2018.1448060
Abstract: ABSTRACT Introduction: Pharmacotherapy with visual cycle modulators (VCMs) is under investigation for retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardt macular dystrophy (SMD) and nonexudative age-related macular degeneration (AMD), all blinding diseases that lack effective… read more here.
Keywords: vcms; pharmacotherapy retinal; retinal disease; visual cycle ... See more keywords
RNA‐seq analysis of ageing human retinal pigment epithelium: Unexpected up‐regulation of visual cycle gene transcription
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16569
Abstract: Ageing presents adverse effects on the retina and is the primary risk factor for age‐related macular degeneration (AMD). We report the first RNA‐seq analysis of age‐related transcriptional changes in the human retinal pigment epithelium (RPE),… read more here.
Keywords: transcription; seq analysis; human retinal; cycle ... See more keywords
In situ autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids.
Sign Up to like & getrecommendations! Published in 2022 at "Biomedical optics express"
DOI: 10.1364/boe.455783
Abstract: Photoreceptors are the key functional cell types responsible for the initiation of vision in the retina. Phototransduction involves isomerization and conversion of vitamin A compounds, known as retinoids, and their recycling through the visual cycle.… read more here.
Keywords: autofluorescence lifetime; visual cycle; situ autofluorescence; retinal organoids ... See more keywords