Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer’s disease
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DOI: 10.1080/14756366.2021.1993845
Abstract: Abstract A novel series of chalcone-Vitamin E-donepezil hybrids was designed and developed based on multitarget-directed ligands (MTDLs) strategy for treating Alzheimer’s disease (AD). The biological results revealed that compound 17f showed good AChE inhibitory potency… read more here.
Keywords: alzheimer disease; chalcone vitamin; multi target; vitamin donepezil ... See more keywords