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Published in 2019 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12060
Abstract: Vitamin B6 is present in our diet in many forms, however, only pyridoxal 5′‐phosphate (PLP) can function as a cofactor for enzymes. The intestine absorbs nonphosphorylated B6 vitamers, which are converted by specific enzymes to…
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Keywords:
plp;
vitamin metabolism;
metabolism;
role plp ... See more keywords
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Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.423
Abstract: Lipidomics is going to leave its role of “Cinderella” of omics technologies. Innovative mass spectrometry and bioinformatics technology is bursting into the omics scene and this is leading lipid science to gain renewed attention and…
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Keywords:
redox lipidomics;
vitamin metabolism;
role;
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Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.07.006
Abstract: Background & Aims Systemic retinol (vitamin A) homeostasis is controlled by the liver, involving close collaboration between hepatocytes and hepatic stellate cells (HSCs). Genetic variants in retinol metabolism (PNPLA3 and HSD17B13) are associated with non-alcoholic…
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Keywords:
vitamin metabolism;
metabolism;
hepatic vitamin;
vitamin ... See more keywords
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Published in 2020 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2020.05.004
Abstract: BACKGROUND Diagnosis of pyoderma gangrenosum, acne and hidradenitis suppurativa (PASH) and pyogenic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PAPASH) patients, in spite of recently identified genetic variations, is just clinical, since most patients do…
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Keywords:
exome sequencing;
vitamin metabolism;
metabolism;
hidradenitis suppurativa ... See more keywords
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Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38613-8
Abstract: Serum 1,25(OH)2D and 24,25(OH)2D are decreased in CKD. Megalin in proximal tubular epithelial cells reabsorbs glomerular-filtered 25(OH)D-DBP complex to convert 25(OH)D to 1,25(OH)2D and 24,25(OH)2D. Urinary C-megalin excretion is increased via exocytosis from injured nephrons…
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Keywords:
vitamin metabolism;
megalin excretion;
urinary megalin;
megalin ... See more keywords
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Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13581
Abstract: Recurrent pregnancy loss (RPL) is a common disease characterized by immune dysfunction and vitamin D deficiency. This study aimed to investigate vitamin D metabolism and γδT cell phenotypes at the maternal–fetal interface in women with…
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Keywords:
vitamin metabolism;
recurrent pregnancy;
pregnancy;
crosstalk trophoblasts ... See more keywords
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Published in 2017 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.13464
Abstract: Vitamin D that is synthesized in the skin or is ingested undergoes sequential steps of metabolic activation via a cascade of cytochrome P450 enzymatic hydroxylations in the liver and kidney to produce 1α,25‐dihydroxyvitamin D (1α,25(OH)2D).…
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Keywords:
marrow derived;
kidney;
vitamin metabolism;
chronic kidney ... See more keywords
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Published in 2022 at "Hormone Research in Paediatrics"
DOI: 10.1159/000527011
Abstract: Rickets was a major public health problem dating from Roman times, and medical descriptions of rickets date from the 17th century. Sniadecki first advocated treatment by exposure to sunshine in 1822; contemporaneously, several British physicians…
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Keywords:
metabolism;
vitamin metabolism;
rickets vitamin;
hydroxylase ... See more keywords
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Published in 2020 at "Annals of Clinical Biochemistry"
DOI: 10.1177/0004563219897691
Abstract: Disorders of vitamin D metabolism have only recently become more widely recognized. In 2011, a series reported six children with familial idiopathic infantile hypercalcaemia, a condition in which patients develop hypercalcaemia following bolus vitamin D…
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Keywords:
supplementation;
vitamin metabolism;
pregnancy;
vitamin supplementation ... See more keywords
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Published in 2018 at "Vascular Medicine"
DOI: 10.1177/1358863x17751258
Abstract: Little is known about whether markers of vitamin D metabolism are associated with the development of abdominal aortic aneurysm (AAA), though these markers have been linked to other cardiovascular diseases. We tested the hypotheses that…
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Keywords:
incident aaa;
risk;
vitamin metabolism;
markers vitamin ... See more keywords
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Published in 2020 at "BMC Medical Genetics"
DOI: 10.1186/s12881-020-01065-3
Abstract: Background Vitamin D metabolism and obesity have been linked by several studies, however the reason for this association is unclear. Our objective was to investigate potential correlations between genetic variants in key enzymes of vitamin…
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Keywords:
vitamin metabolism;
cyp2r1;
bmi;
genetic variants ... See more keywords