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Published in 2021 at "Drug testing and analysis"
DOI: 10.1002/dta.3006
Abstract: Equine neuroaxonal dystrophy/degenerative myeloencephalopathy (eNAD/EDM) is a hereditary, deteriorating central nervous disease in horses. Currently, the only way to confirm eNAD/EDM is through a postmortem histological evaluation of the central nervous system. Vitamin E, specifically…
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Keywords:
enad edm;
vitamin metabolites;
metabolites equine;
equine urine ... See more keywords
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Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0200-6
Abstract: AbstractVitamin D3 and its metabolites are lipophilic molecules with low aqueous solubility and must be transported bound to plasma carrier proteins, primarily to vitamin D binding protein (DBP). The biological functions of vitamin D3 metabolites…
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Keywords:
vitamin metabolites;
vitamin binding;
binding protein;
vitamin ... See more keywords
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Published in 2023 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00523
Abstract: Alzheimer’s disease is characterized by the presence in the brain of amyloid plaques formed by the aberrant deposition of the amyloid-β peptide (Aβ). Since many vitamins are dysregulated in this disease, we explored whether these…
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Keywords:
resilience;
aggregation;
vitamin metabolites;
vitamin vitamin ... See more keywords
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Published in 2022 at "Acta Anaesthesiologica Scandinavica"
DOI: 10.1111/aas.14137
Abstract: Despite multiple studies suggesting that low 25(OH)D‐vitamin levels are associated with worse outcomes in critically ill individuals, attempts to mitigate the outcomes by fixed dose enteral supplementation unguided by baseline or target blood levels have…
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Keywords:
changes vitamin;
time critical;
metabolites time;
vitamin metabolites ... See more keywords
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Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000609
Abstract: A physiologically based pharmacokinetic (PBPK) model of vitamin D3 and metabolites [25(OH)D3, 1,25(OH)2D3, and 24,25(OH)2D3] is presented. In this study, patients with 25(OH)D3 plasma concentrations below 30 ng/ml were studied after a single dose of…
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Keywords:
physiologically based;
based pharmacokinetic;
vitamin metabolites;
pbpk model ... See more keywords
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Published in 2019 at "Journal of Chemistry"
DOI: 10.1155/2019/1279036
Abstract: From studies on different species and in cell culture systems, it has been suggested that vitamin D metabolites might affect the metabolism and elimination of xenobiotics. Although most studies performed on rodents and cell cultures…
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Keywords:
administration vitamin;
vitamin metabolites;
treatment;
metabolites affects ... See more keywords
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Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci98680
Abstract: Genetic forms of vitamin D–dependent rickets (VDDRs) are due to mutations impairing activation of vitamin D or decreasing vitamin D receptor responsiveness. Here we describe two unrelated patients with early-onset rickets, reduced serum levels of…
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Keywords:
vitamin dependent;
vitamin metabolites;
cyp3a4;
dependent rickets ... See more keywords
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Published in 2021 at "Journal of Veterinary Diagnostic Investigation"
DOI: 10.1177/10406387211005433
Abstract: Vitamin E deficiencies can impact normal growth and development in humans and animals, and assessment of circulating levels of vitamin E and its metabolites may be an important endpoint for evaluation. Development of a sensitive…
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Keywords:
vitamin;
plasma serum;
vitamin metabolites;
quantification ... See more keywords
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Published in 2021 at "Vascular Health and Risk Management"
DOI: 10.2147/vhrm.s312376
Abstract: Background Vitamin D deficiency is considered an emerging health problem that affects at least one billion patients worldwide. Calcitriol 1,25(OH)2D3 has several systemic effects, including anti-inflammatory, anti-thrombotic and anti-atherosclerotic impacts that explain its cardioprotective effects.…
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Keywords:
acs;
vitamin metabolites;
coronary angiography;
undergoing coronary ... See more keywords
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Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11091288
Abstract: The brain’s supply with vitamin D is poorly understood. Therefore, the present study aimed to determine 25-hydroxy vitamin D3 (25(OH)D) and 24,25-dihydroxy vitamin D (24,25(OH)2D3) in serum and cerebrospinal fluid (CSF) from individuals with intact…
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Keywords:
vitamin metabolites;
serum;
csf;
vitamin ... See more keywords
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Published in 2022 at "Cancers"
DOI: 10.3390/cancers14061560
Abstract: Simple Summary Recent research on prostate cancer and vitamin D is controversial. We measured three vitamin D3 metabolites in 32 selected prostate cancer patients after surgery at four time points over four years. Within a…
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Keywords:
zoledronic acid;
treatment;
vitamin metabolites;
vitamin ... See more keywords