Vitexin prevents Aβ proteotoxicity in transgenic Caenorhabditis elegans model of Alzheimer's disease by modulating unfolded protein response
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22632
Abstract: Alzheimer's disease (AD) accounts for an estimated 60% to 80% of all dementia cases. The present study is aimed at evaluating the neuroprotective efficacy of vitexin, an apigenin flavone glycoside using transgenic Caenorhabditis elegans strain… read more here.
Keywords: vitexin; unfolded protein; alzheimer disease; protein response ... See more keywords
Use of mycorrhizal fungi releases the application of organic fertilizers to increase the production of leaf vitexin in yellow passion fruit.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.10197
Abstract: BACKGROUND Low-cost organic fertilizers, such as coconut powder and vermicompost, and arbuscular mycorrhizal fungi (AMF) may benefit the Passiflora edulis f. flavicarpa plant. However, it has not been established whether the joint application of these… read more here.
Keywords: vitexin; production; mycorrhizal fungi; application ... See more keywords
Molecular mechanism of anti‐adipogenic effect of vitexin in differentiating hMSCs
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7300
Abstract: In this study, we evaluated a detailed molecular mechanism of anti‐adipogenic activity of vitexin, apigenin flavone glucoside, present in germinated fenugreek seeds, in differentiating human mesenchymal stem cells (hMSCs). The lipid content of differentiated adipocytes… read more here.
Keywords: vitexin; anti adipogenic; mechanism anti; effect ... See more keywords
Separation of Vitexin and Iso-vitexin from Mung Bean Seed Coats Using a Three-Zone Simulated Moving Bed (SMB)
Sign Up to like & getrecommendations! Published in 2021 at "Waste and Biomass Valorization"
DOI: 10.1007/s12649-021-01493-z
Abstract: Vitexin and iso-vitexin, potential bioactive compounds for nutraceutical or pharmaceutical applications, are natural phenolic compounds present in mung bean seed coats. These compounds could be extracted using ethanol-based solvent. Improving the purity of vitexin and… read more here.
Keywords: separation; vitexin iso; seed; vitexin ... See more keywords
Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.104
Abstract: The molecular mechanisms involved in ER stress-induced post myocardial injury remain elusive. In this study, we have investigated the molecular mechanism of ER stress-mediated myocyte death in Isoproterenol (ISO) induced myocardial infarction and its inhibition… read more here.
Keywords: myocardial injury; vitexin; stress; post myocardial ... See more keywords
N-trimethyl chitosan coated targeting nanoparticles improve the oral bioavailability and antioxidant activity of vitexin.
Sign Up to like & getrecommendations! Published in 2022 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2022.119273
Abstract: Vitexin is a flavonoid which exerted many protective activities. However, the low bioavailability discounts the in vivo effects of vitexin. This study designed vitexin loaded bilayer nanoparticles by the assembly of soybean peptides and the… read more here.
Keywords: vitexin; trimethyl chitosan; bioavailability antioxidant; antioxidant activity ... See more keywords
Vitexin ameliorates chronic stress plub high fat diet-induced nonalcoholic fatty liver disease by inhibiting inflammation.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173264
Abstract: Evidences showed that chronic stress (CS) can aggravate the situation of nonalcoholic fatty liver disease (NAFLD). Vitexin is one of the major components in hawthorn, which is widely used to reduce blood lipid. This study… read more here.
Keywords: high fat; fat diet; chronic stress; vitexin ... See more keywords
Vitexin inhibits acrylamide-induced neuroinflammation and improves behavioral changes in zebrafish larvae.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2019.106811
Abstract: Neuroinflammation is crucial for the pathophysiological hallmarks of many neurodegenerative disorders. Hyperactivated microglia has long been implicated as a detrimental player in regulating unresolvable inflammatory insults which cause damage to neurons. In the context of… read more here.
Keywords: zebrafish larvae; vitexin; induced neuroinflammation; larvae ... See more keywords
Vitexin Protects against Dextran Sodium Sulfate-Induced Colitis in Mice and Its Potential Mechanisms.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05177
Abstract: Vitexin, one of the major active components in hawthorn, has been shown to possess multiple pharmacological activities. Here, we sought to investigate the effect of vitexin on an ameliorating dextran sodium sulfate (DSS)-induced ulcerative colitis… read more here.
Keywords: colitis mice; vitexin; sodium sulfate; colitis ... See more keywords
Vitexin mitigates myocardial ischemia reperfusion-induced damage by inhibiting excessive autophagy to suppress apoptosis via the PI3K/Akt/mTOR signaling cascade
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra12151b
Abstract: Myocardial ischemia reperfusion (MI/R) injury is reported to induce apoptosis and autophagy of myocardial cells and contribute to adverse cardiovascular outcomes. Vitexin, a flavonoids compound, exhibited anti-inflammatory, anti-oxidative and antitumor effects in various studies. Here,… read more here.
Keywords: vitexin; apoptosis; pi3k akt; autophagy ... See more keywords
Vitexin inhibits APEX1 to counteract the flow-induced endothelial inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2115158118
Abstract: Vascular endothelial cells are exposed to shear stresses with disturbed vs. laminar flow patterns, which lead to proinflammatory vs. antiinflammatory phenotypes, respectively. Effective treatment against endothelial inflammation and the consequent atherogenesis requires the identification of… read more here.
Keywords: induced endothelial; endothelial inflammation; vitexin; flow induced ... See more keywords