Profiling of idiopathic macular hole vitreous proteome identifies the role of extracellular matrix remodelling, epithelial-mesenchymal transformation and unfolded protein-response pathways.
Sign Up to like & getrecommendations! Published in 2023 at "Indian journal of ophthalmology"
DOI: 10.4103/ijo.ijo_2068_22
Abstract: Purpose To analyze and describe the proteome of the vitreous humour in eyes with idiopathic macular holes. Methods We performed mass spectrometry (MS)-based label-free quantitative analysis of the vitreous proteome of idiopathic macular hole (IMH)… read more here.
Keywords: extracellular matrix; unfolded protein; idiopathic macular; vitreous proteome ... See more keywords
System-wide vitreous proteome dissection reveals impaired sheddase activity in diabetic retinopathy
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DOI: 10.7150/thno.72947
Abstract: Rationale: Diabetic retinopathy (DR) is a major complication of diabetes mellitus causing significant vision loss. DR is a multifactorial disease involving changes in retinal microvasculature and neuronal layers, and aberrations in vascular endothelial growth factors… read more here.
Keywords: ectodomain shedding; vitreous proteome; diabetic retinopathy; angiogenesis ... See more keywords