In vitro affinity maturation to improve the efficacy of a hypoxia-inducible factor 1α single-domain intrabody.
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DOI: 10.1016/j.bbrc.2020.06.097
Abstract: Affinity is an important property of therapeutic antibodies, so improving affinity is critical to the biological activity and clinical efficacy. An anti-HIF-1α nanobody, VHH212, was screened via a native ribosome display library with a 26.6 nM… read more here.
Keywords: intrabody; vitro affinity; maturation improve; affinity ... See more keywords