Overcoming scientific barriers in the transition from in vivo to non-animal batch testing of human and veterinary vaccines.
Sign Up to like & getrecommendations! Published in 2021 at "Expert review of vaccines"
DOI: 10.1080/14760584.2021.1977628
Abstract: INTRODUCTION Before release, vaccine batches are assessed for quality to evaluate whether they meet the product specifications. Vaccine batch tests, in particular of inactivated and toxoid vaccines, still largely rely on in vivo methods. Improved… read more here.
Keywords: vaccines overcoming; scientific barriers; vivo; vitro alternatives ... See more keywords
In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models—A Perspective
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DOI: 10.3389/fbioe.2020.00549
Abstract: When assessing the risk and hazard of a non-pharmaceutical compound, the first step is determining acute toxicity, including toxicity following inhalation. Inhalation is a major exposure route for humans, and the respiratory epithelium is the… read more here.
Keywords: inhalation toxicity; toxicity; vitro alternatives; acute inhalation ... See more keywords
Evaluating Antivenom Efficacy against Echis carinatus Venoms—Screening for In Vitro Alternatives
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14070481
Abstract: In India, polyvalent antivenom is the mainstay treatment for snakebite envenoming. Due to batch-to-batch variation in antivenom production, manufacturers have to estimate its efficacy at each stage of IgG purification using the median effective dose… read more here.
Keywords: venom; antivenom efficacy; echis carinatus; efficacy ... See more keywords