Synthesis and in vitro anticancer activity of 23(23′)E-benzylidenespirostanols derived from steroid sapogenins
Sign Up to like & getrecommendations! Published in 2017 at "Steroids"
DOI: 10.1016/j.steroids.2017.08.017
Abstract: Graphical abstract Figure. No Caption available. HighlightsCondensation of spirostanes and benzaldehyde led to benzylidenspirostanes.Saponification of benzylidenspirostanes led to benzylidenspirostanols.New benzylidenspirostanols showed cytotoxicity against three cancer cell lines.The most active compound bears a trans AB core… read more here.
Keywords: cell line; anticancer activity; steroid sapogenins; synthesis vitro ... See more keywords
Phytochemical constituents, in-vitro anticancer activity and computational studies of Cymbopogon schoenanthus.
Sign Up to like & getrecommendations! Published in 2023 at "Natural product research"
DOI: 10.1080/14786419.2023.2208360
Abstract: The cytotoxic effects of Cymbopogon schoenanthus L. aerial part ethanol extract were examined against some cancer cell lines, and HUVEC normal cell lines using MTT assay. The ethanolic extract was prepared by ultrasonic-assisted extraction and… read more here.
Keywords: phytochemical constituents; vitro anticancer; cymbopogon schoenanthus; cell lines ... See more keywords
Synthesis and in vitro Anticancer Activity of Novel Heterocycles Utilizing Thiophene Incorporated Thioureido Substituent as Precursors.
Sign Up to like & getrecommendations! Published in 2020 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2019.5571
Abstract: Ethyl 2-(3-allylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1) was used as a building block for synthesis of new heterocycles. Pyrimidine and thiazole moieties were achieved upon condensation of compound 1 with various reagents such as chloroacetic acid, dietyl malonate, ninhydrin,… read more here.
Keywords: thiophene; activity; anticancer activity; activity novel ... See more keywords
In Vitro Anticancer Drug Sensitivity Sensing through Single-Cell Raman Spectroscopy
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DOI: 10.3390/bios11080286
Abstract: Traditional in vitro anticancer drug sensitivity testing at the population level suffers from lengthy procedures and high false positive rates. To overcome these defects, we built a confocal Raman microscopy sensing system and proposed a… read more here.
Keywords: single cell; raman; drug; vitro anticancer ... See more keywords
Ruthenium(II) and Platinum(II) Complexes with Biologically Active Aminoflavone Ligands Exhibit In Vitro Anticancer Activity
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22147568
Abstract: Continuing our studies on the mechanisms underlying the cytotoxicity of potential drugs, we have described several aspects of the in vitro anticancer activity of ruthenium(II) and platinum(II) complexes with bioactive, synthetic aminoflavone ligands. We examined… read more here.
Keywords: ruthenium; aminoflavone; platinum; anticancer activity ... See more keywords
Synthesis, Nanoformulations, and In Vitro Anticancer Activity of N-Substituted Side Chain Neocryptolepine Scaffolds
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27031024
Abstract: The naturally occurring neocryptolepine (5-Methylindolo [2,3-b]quinoline) and its analogs exhibited prominent anticancer and antimalarial activity. However, the main problem of this class of compounds is their poor aqueous solubility, hampering their bioavailability and preventing their… read more here.
Keywords: anticancer activity; vitro anticancer; synthesis nanoformulations; sio2nps ... See more keywords
In Vitro Anticancer Screening, Molecular Docking and Antimicrobial Studies of Triazole-Based Nickel(II) Metal Complexes
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196548
Abstract: Herein we describe the synthesis of a series of nickel(II) complexes (C1–C3) with Schiff bases (HL1–HL3) derived from 4-amino-5-mercapto-3-methyl-1,2,4-triazole and ortho/meta/para-nitrobenzaldehyde having composition [Ni(L)2(H2O)2]. The obtained ligands and their complexes were characterized using physico-chemical techniques… read more here.
Keywords: molecular docking; schiff bases; metal complexes; vitro anticancer ... See more keywords
N-Rich, Polyphenolic Porous Organic Polymer and Its In Vitro Anticancer Activity on Colorectal Cancer
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DOI: 10.3390/molecules27217326
Abstract: N-rich organic materials bearing polyphenolic moieties in their building networks and nanoscale porosities are very demanding in the context of designing efficient biomaterials or drug carriers for the cancer treatment. Here, we report the synthesis… read more here.
Keywords: anticancer activity; vitro anticancer; organic polymer; polyphenolic porous ... See more keywords
Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020626
Abstract: Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives. 4-Fluoro- and 4-nitrobenzyl-1,2,3-triazole-containing hybrid molecules were prepared. The mono- and bis-coupled hybrids were… read more here.
Keywords: vitro anticancer; synthesis vitro; flavone triazole; triazole hybrids ... See more keywords
In Vitro Anticancer Activity Screening of Novel Fused Thiophene Derivatives as VEGFR-2/AKT Dual Inhibitors and Apoptosis Inducers
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DOI: 10.3390/ph15060700
Abstract: Protein kinases are seen as promising targets in controlling cell proliferation and survival in treating cancer where fused thiophene synthon was utilized in many kinase inhibitors approved by the FDA. Accordingly, this work focused on… read more here.
Keywords: cell; vegfr akt; vitro anticancer; activity ... See more keywords