The in Vitro Antiplasmodial and Antiproliferative Activity of New Ferrocene‐Based α‐Aminocresols Targeting Hemozoin Inhibition and DNA Interaction
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DOI: 10.1002/cbic.202000132
Abstract: The conjugation of organometallic complexes to known bioactive organic frameworks is a proven strategy revered for devising new drug molecules with novel modes of action. This approach holds great promise for the generation of potent… read more here.
Keywords: hemozoin inhibition; antiplasmodial antiproliferative; dna; vitro antiplasmodial ... See more keywords
Fluorene‐Chloroquine Hybrids: Synthesis, in vitro Antiplasmodial Activity, and Inhibition of Heme Detoxification Machinery of Plasmodium falciparum
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DOI: 10.1002/cmdc.202200414
Abstract: Fluorene‐chloroquine hybrids have been identified as a new promising class of antiplasmodial agents. The most active compound 9 d exhibited good in vitro antiplasmodial activity against a chloroquine‐sensitive NF54 strain of the human malaria parasite Plasmodium falciparum… read more here.
Keywords: inhibition; heme; fluorene chloroquine; chloroquine hybrids ... See more keywords
In vitro antiplasmodial activity of Withania frutescens—Solanaceae
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DOI: 10.1016/j.eujim.2017.08.009
Abstract: Abstract Introduction Drugs resistant Plasmodium falciparum is a recurring issue that threatens public health. New antiplasmodial drugs are needed to overcome this problem. The aim of this study was to characterize in vitro antiplasmodial activity… read more here.
Keywords: antiplasmodial activity; frutescens solanaceae; withania frutescens; vitro antiplasmodial ... See more keywords
Growth, secondary metabolite production, and in vitro antiplasmodial activity of Sonchus arvensis L. callus under dolomite [CaMg(CO3)2] treatment
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DOI: 10.1371/journal.pone.0254804
Abstract: Malaria is still a global health problem. Plasmodium is a single-cell protozoan parasite that causes malaria and is transmitted to humans through the female Anopheles mosquito. The previous study showed that Sonchus arvensis L. callus… read more here.
Keywords: production; arvensis callus; antiplasmodial activity; vitro antiplasmodial ... See more keywords