Can in vitro assays account for interactions between inorganic co-contaminants observed during in vivo relative bioavailability assessment?
Sign Up to like & getrecommendations! Published in 2018 at "Environmental pollution"
DOI: 10.1016/j.envpol.2017.10.089
Abstract: In vitro assays act as surrogate measurements of relative bioavailability (RBA) for inorganic contaminants. The values derived from these assays are routinely used to refine human health risk assessments (HHRA). Extensive in vitro research has been performed… read more here.
Keywords: relative bioavailability; inorganic contaminants; vitro assays; bioavailability ... See more keywords
On selecting a minimal set of in vitro assays to reliably determine estrogen agonist activity
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.09.022
Abstract: ABSTRACT The US EPA is charged with screening chemicals for their ability to be endocrine disruptors through interaction with the estrogen, androgen and thyroid axes. The agency is exploring the use of high‐throughput in vitro… read more here.
Keywords: selecting minimal; vitro; vitro assays; set vitro ... See more keywords
Discovery of novel bacterial topoisomerase I inhibitors by use of in silico docking and in vitro assays
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-19944-4
Abstract: Topoisomerases are important targets for antibacterial and anticancer therapies. Bacterial topoisomerase I remains to be exploited for antibiotics that can be used in the clinic. Inhibitors of bacterial topoisomerase I may provide leads for novel… read more here.
Keywords: topoisomerase inhibitors; vitro assays; topoisomerase; silico screening ... See more keywords
In vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5‐HT2AR
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15570
Abstract: Serotonergic psychedelics are substances that induce alterations in mood, perception, and thought, and have the activation of serotonin (5‐HT) 2A receptors (5‐HT2ARs) as a main pharmacological mechanism. Besides their appearance on the (illicit) drug market,… read more here.
Keywords: functional characterization; assays monitor; vitro assays; ht2ar ... See more keywords
Review on In silico Methods, High-throughput Screening Techniques, and Cell Culture Based In Vitro Assays for SARS-CoV-2..
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220627121416
Abstract: The COVID-19 outbreak caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to have high incidence and mortality rate globally. To meet the increasingly growing demand for new therapeutic drugs and vaccines, researchers… read more here.
Keywords: review; silico methods; vitro assays; methods high ... See more keywords
Assessment of the Angiogenic Potential of 2-Deoxy-D-Ribose Using a Novel in vitro 3D Dynamic Model in Comparison With Established in vitro Assays
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2019.00451
Abstract: Angiogenesis is a highly ordered physiological process regulated by the interaction of endothelial cells with an extensive variety of growth factors, extracellular matrix components and mechanical stimuli. One of the most important challenges in tissue… read more here.
Keywords: angiogenesis; vitro assays; angiogenic potential; model ... See more keywords
Evaluation of in vitro Assays to Assess the Modulation of Dendritic Cells Functions by Therapeutic Antibodies and Aggregates
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00601
Abstract: Therapeutic antibodies have the potential to induce immunogenicity leading to the development of anti-drug antibodies (ADA) that consequently may result in reduced serum drug concentrations, a loss of efficacy or potential hypersensitivity reactions. Among other… read more here.
Keywords: therapeutic antibodies; vitro assays; drug; dendritic cells ... See more keywords
Assessing Fish Immunotoxicity by Means of In Vitro Assays: Are We There Yet?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.835767
Abstract: There is growing awareness that a range of environmental chemicals target the immune system of fish and may compromise the resistance towards infectious pathogens. Existing concepts to assess chemical hazards to fish, however, do not… read more here.
Keywords: immune cells; immunotoxicity; vitro assays; fish immunotoxicity ... See more keywords
Development of In Vitro Assays for Advancing Radioimmunotherapy against Brain Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10081796
Abstract: Glioblastoma (GBM) is the most common primary brain tumor. Due to high resistance to treatment, local invasion, and a high risk of recurrence, GBM patient prognoses are often dismal, with median survival around 15 months.… read more here.
Keywords: cell; brain tumors; brain; vitro assays ... See more keywords
An Overview of In Vitro Assays of 64Cu-, 68Ga-, 125I-, and 99mTc-Labelled Radiopharmaceuticals Using Radiometric Counters in the Era of Radiotheranostics
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13071210
Abstract: Radionuclides are unstable isotopes that mainly emit alpha (α), beta (β) or gamma (γ) radiation through radiation decay. Therefore, they are used in the biomedical field to label biomolecules or drugs for diagnostic imaging applications,… read more here.
Keywords: radiometric counters; using radiometric; vitro assays; 64cu 68ga ... See more keywords
Physicochemical Characterization and Biological Activities of Black and White Garlic: In Vivo and In Vitro Assays †
Sign Up to like & getrecommendations! Published in 2019 at "Foods"
DOI: 10.3390/foods8060220
Abstract: White and three types of black garlic (13, 32, and 45 days of aging, named 0C1, 1C2, and 2C1, respectively) were selected to study possible differences in their nutraceutic potential. For this purpose, garlic were… read more here.
Keywords: white garlic; vivo vitro; vivo; vitro assays ... See more keywords