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   Articles with "vitro assays" as a keyword



Application of in vitro pulmonary models for hazard screening of silica particles

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recommendations! Published in 2025 at "Archives of Toxicology"

DOI: 10.1007/s00204-025-04100-5

Abstract: There is an increasing need for new approach methodologies (NAMs) for safety assessment of nanomaterials (NMs) in order to keep pace with innovation. In vitro assays are useful tools during pre-market hazard screening approaches of… read more here.

Keywords: silica; vitro assays; hazard screening; silica particles ... See more keywords

Extrapolation of cytotoxic masked effects in planar in vitro assays

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recommendations! Published in 2024 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-024-05302-z

Abstract: The masking of specific effects in in vitro assays by cytotoxicity is a commonly known phenomenon. This may result in a partial or complete loss of effect signals. For common in vitro assays, approaches for… read more here.

Keywords: planar vitro; vitro assays; extrapolation cytotoxic; affected signals ... See more keywords

Can in vitro assays account for interactions between inorganic co-contaminants observed during in vivo relative bioavailability assessment?

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recommendations! Published in 2018 at "Environmental pollution"

DOI: 10.1016/j.envpol.2017.10.089

Abstract: In vitro assays act as surrogate measurements of relative bioavailability (RBA) for inorganic contaminants. The values derived from these assays are routinely used to refine human health risk assessments (HHRA). Extensive in vitro research has been performed… read more here.

Keywords: relative bioavailability; inorganic contaminants; vitro assays; bioavailability ... See more keywords

On selecting a minimal set of in vitro assays to reliably determine estrogen agonist activity

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recommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"

DOI: 10.1016/j.yrtph.2017.09.022

Abstract: ABSTRACT The US EPA is charged with screening chemicals for their ability to be endocrine disruptors through interaction with the estrogen, androgen and thyroid axes. The agency is exploring the use of high‐throughput in vitro… read more here.

Keywords: selecting minimal; vitro; vitro assays; set vitro ... See more keywords

Discovery of novel bacterial topoisomerase I inhibitors by use of in silico docking and in vitro assays

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-19944-4

Abstract: Topoisomerases are important targets for antibacterial and anticancer therapies. Bacterial topoisomerase I remains to be exploited for antibiotics that can be used in the clinic. Inhibitors of bacterial topoisomerase I may provide leads for novel… read more here.

Keywords: topoisomerase inhibitors; vitro assays; topoisomerase; silico screening ... See more keywords

In vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5‐HT2AR

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recommendations! Published in 2022 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.15570

Abstract: Serotonergic psychedelics are substances that induce alterations in mood, perception, and thought, and have the activation of serotonin (5‐HT) 2A receptors (5‐HT2ARs) as a main pharmacological mechanism. Besides their appearance on the (illicit) drug market,… read more here.

Keywords: functional characterization; assays monitor; vitro assays; ht2ar ... See more keywords

In vitro assays for clinical isolates of sequence type 131 Escherichia coli do not recapitulate in vivo infectivity using a murine model of urinary tract infection

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recommendations! Published in 2024 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.01511-24

Abstract: ABSTRACT Sequence type 131 isolates are a major cause of cystitis and pyelonephritis. Many studies rely solely on in vitro assays to screen for bacterial virulence factors associated with the pathogenicity of clinical isolates of… read more here.

Keywords: murine model; vitro assays; clinical isolates; model ... See more keywords

Review on In silico Methods, High-throughput Screening Techniques, and Cell Culture Based In Vitro Assays for SARS-CoV-2..

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recommendations! Published in 2022 at "Current medicinal chemistry"

DOI: 10.2174/0929867329666220627121416

Abstract: The COVID-19 outbreak caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to have high incidence and mortality rate globally. To meet the increasingly growing demand for new therapeutic drugs and vaccines, researchers… read more here.

Keywords: review; silico methods; vitro assays; methods high ... See more keywords

Andrographolide demonstrates anti-proliferative activity in oral cancer by promoting apoptosis, the programmed cell death process

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recommendations! Published in 2024 at "Iranian Journal of Basic Medical Sciences"

DOI: 10.22038/ijbms.2024.76691.16599

Abstract: Objective(s): Andrographolide has been studied on different types of human cancer cells, but very few studies have been conducted on oral cancer. The study aimed to evaluate the anticancer potential of Andrographolide on an oral… read more here.

Keywords: cancer; vitro assays; oral cancer; anti proliferative ... See more keywords

Assessment of the Angiogenic Potential of 2-Deoxy-D-Ribose Using a Novel in vitro 3D Dynamic Model in Comparison With Established in vitro Assays

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recommendations! Published in 2019 at "Frontiers in Bioengineering and Biotechnology"

DOI: 10.3389/fbioe.2019.00451

Abstract: Angiogenesis is a highly ordered physiological process regulated by the interaction of endothelial cells with an extensive variety of growth factors, extracellular matrix components and mechanical stimuli. One of the most important challenges in tissue… read more here.

Keywords: angiogenesis; vitro assays; angiogenic potential; model ... See more keywords

Evaluation of in vitro Assays to Assess the Modulation of Dendritic Cells Functions by Therapeutic Antibodies and Aggregates

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recommendations! Published in 2019 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2019.00601

Abstract: Therapeutic antibodies have the potential to induce immunogenicity leading to the development of anti-drug antibodies (ADA) that consequently may result in reduced serum drug concentrations, a loss of efficacy or potential hypersensitivity reactions. Among other… read more here.

Keywords: therapeutic antibodies; vitro assays; drug; dendritic cells ... See more keywords