Discovery of novel MurB inhibitors through common feature pharmacophore–based virtual screening and in vitro biological evaluation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Chinese Chemical Society"
DOI: 10.1002/jccs.70127
Abstract: MurB, a key enzyme involved in bacterial cell wall synthesis, has become an important target in antibacterial drug research due to its crucial role in inhibiting peptidoglycan biosynthesis. In this study, a virtual screening workflow… read more here.
Keywords: virtual screening; evaluation; vitro biological; feature pharmacophore ... See more keywords
Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents
Sign Up to like & getrecommendations! Published in 2024 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-024-03235-x
Abstract: Kinetoplastids are a group of flagellated protozoans including medically important parasites of the genus Trypanosoma and Leishmania. The corresponding diseases have afflicted humans for centuries. In an effort to combat kinetoplastid infections, a set of… read more here.
Keywords: trypanosoma; vitro biological; synthesis vitro; biological activity ... See more keywords
In vitro biological, catalytic, and DFT studies of some iron(III) N-ligated complexes
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Papers"
DOI: 10.1007/s11696-019-01009-z
Abstract: Fe(III) complexes, [Fe(CH 3 CN) 6 ][X] 3 and [Fe(CH 3 CH 2 CN) 6 ][X] 3 (where X: counter anion = B{C 6 H 3 (m-CF 3 ) 2 } 4 ) − and B(C 6… read more here.
Keywords: dft studies; catalytic dft; vitro biological; biological catalytic ... See more keywords
Synthesis, characterization, in silico, and in vitro biological screening of coordination compounds with 1,2,4-triazine based biocompatible ligands and selected 3d-metal ions
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e05144
Abstract: A bidentate Schiff base ligand, MHMMT, obtained from 1,2,4-triazine derivative and 4-hydroxy-3-methoxy benzaldehyde and its Fe(III), Co(II), Ni(II), Cu(II), and Zn(II) complexes were synthesised in ethanolic media and characterized by various analytical techniques like elemental… read more here.
Keywords: biological screening; silico vitro; vitro biological; characterization silico ... See more keywords
In vitro biological propensities and chemical profiling of Euphorbia milii Des Moul (Euphorbiaceae): A novel source for bioactive agents
Sign Up to like & getrecommendations! Published in 2019 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2018.12.062
Abstract: Abstract The plants of Euphorbia genus have been extensively studied for their nutritive and therapeutic purposes. The present research is the foremost effort to investigate and compare the biological activities and chemical composition of dichloromethane… read more here.
Keywords: biological propensities; source bioactive; des moul; vitro biological ... See more keywords
Phytochemical profiling, in vitro biological properties and in silico studies on Caragana ambigua stocks (Fabaceae): A comprehensive approach
Sign Up to like & getrecommendations! Published in 2019 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2019.01.044
Abstract: Abstract Plant from Caragana genus have interesting potential in folklore medicines and have been explored for various pharmacological activities. The aim of this study was to probe into the chemical and biological effects of different… read more here.
Keywords: ambigua stocks; vitro biological; profiling vitro; phytochemical profiling ... See more keywords
Synthesis, computational predictions of selective bioactive nicotinamide derivatives and in vitro biological evaluations
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.06.048
Abstract: Abstract A series of nicotinamide derivatives were designed and studied in silico molecular docking predictions against inflammatory responsible enzymes (cyclooxygenase-1(1PGG) and cyclooxygenase-2 (4-COX)). The well-predicted compounds were synthesized, characterized by the spectroscopic techniques namely, Proton… read more here.
Keywords: predictions selective; nicotinamide derivatives; synthesis computational; vitro biological ... See more keywords
Supramolecular architecture, thermal, Quantum chemical analysis and in vitro biological properties on sulfate salt of 4-aminoantipyrine
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131033
Abstract: Abstract A new hydrogen-bonded single crystals of 4-aminoantipyrinium bisulfate monohydrate (4AAPS) have been grown by conventional solution growth technique. The grown crystal crystallized in monoclinic, P21/c is the space group determined by Single-crystal X-ray diffraction… read more here.
Keywords: vitro biological; analysis vitro; supramolecular architecture; biological properties ... See more keywords
Physicochemical and in vitro biological evaluations of furazolidone-based β-cyclodextrin complexes in Leishmania amazonensis.
Sign Up to like & getrecommendations! Published in 2018 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2018.06.013
Abstract: Recently, there have been numerous cases of leishmaniasis reported in different Brazilian states. The use of furazolidone (FZD) to treat leishmaniasis has been previously described; however, the drug is associated with adverse effects such as… read more here.
Keywords: amazonensis; furazolidone based; vitro biological; evaluations furazolidone ... See more keywords
Photo-induced synthesis and in vitro biological activity of a Sansalvamide A analog
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.03.042
Abstract: Abstract Photoinduced single electron transfer (SET) cyclization processes for synthesis of a Sansalvamide A analog containing double pharmacophores (cyclicpeptides and O-phthalimide moiety) is described to develop novel antitumor cyclopeptide drug. The resultant compound is active… read more here.
Keywords: biological activity; induced synthesis; photo induced; synthesis vitro ... See more keywords
Electrospun Poly(ε-caprolactone) Fiber Scaffolds Functionalized by the Covalent Grafting of a Bioactive Polymer: Surface Characterization and Influence on in Vitro Biological Response
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b01647
Abstract: The purpose of this study is to present the poly(caprolactone) (PCL) functionalization by the covalent grafting of poly(sodium styrene sulfonate) on electrospun scaffolds using the “grafting from” technique and evaluate the effect of the coating… read more here.
Keywords: biological response; response; covalent grafting; poly caprolactone ... See more keywords