Quantification of freely dissolved effect concentrations in in vitro cell-based bioassays
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02498-3
Abstract: Improved understanding of chemical exposure in in vitro bioassays is required for quantitative in vitro–in vivo extrapolation (QIVIVE). In this study, we quantified freely dissolved concentrations in medium sampled from in vitro cell-based bioassays (Cfree,medium) for… read more here.
Keywords: effect concentrations; medium; cfree medium; freely dissolved ... See more keywords
Assessing Performance of Wastewater Treatment Using in Vitro Cell-based Assays
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Environmental Contamination and Toxicology"
DOI: 10.1007/s00244-021-00900-9
Abstract: Bioanalytical tools, namely in vitro bioassays, can be employed in tandem with chemical analyses to assess the efficacy of wastewater treatment and the potential for adverse effects from the discharges of wastewater into receiving waters.… read more here.
Keywords: vitro cell; treatment; performance; wastewater treatment ... See more keywords
In vitro 3D cell sheet-based model for unraveling scar pathophysiology
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology Letters"
DOI: 10.1016/j.toxlet.2017.07.952
Abstract: Grant IF.00945.2014 and SFRH.BD.119756.2016 (FCT_MCTES), NORTE.08.5369.FSE.000044 (funded by Programa_Operacional_Norte_2020 Fundo Social Europeu), GENE2SKIN Twinning Project, Horizon_2020 (European Commission). read more here.
Keywords: sheet based; unraveling scar; model unraveling; vitro cell ... See more keywords
A Difference between In Vitro and In-Cell Protein Dimer Formation.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00780
Abstract: The high concentration of macromolecules in cells affects the stability of proteins and protein complexes via hard repulsions and chemical interactions, yet few studies have focused on chemical interactions. We characterized the domain-swapped dimer of… read more here.
Keywords: molten globule; difference vitro; vitro cell; chemical interactions ... See more keywords
Engineered in-vitro cell line mixtures and robust evaluation of computational methods for clonal decomposition and longitudinal dynamics in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13338-8
Abstract: Characterization and quantification of tumour clonal populations over time via longitudinal sampling are essential components in understanding and predicting the response to therapeutic interventions. Computational methods for inferring tumour clonal composition from deep-targeted sequencing data… read more here.
Keywords: cell line; engineered vitro; line mixtures; vitro cell ... See more keywords
In vitro cell culture in hollow microfibers with porous structures.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials science"
DOI: 10.1039/c9bm01986c
Abstract: In recent years, there has been a marked increase in tissue engineering research, particularly in the development of electrospun fiber-based substrates as in vitro cell culture platforms. Many scaffolds fabricated via electrospinning have focused on… read more here.
Keywords: culture hollow; cell culture; hollow microfibers; vitro cell ... See more keywords
In vitro cell-based models of drug-induced hepatotoxicity screening: progress and limitation
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2022.2064487
Abstract: Abstract Drug-induced liver injury (DILI) is one of the major causes of post-approval withdrawal of therapeutics. As a result, there is an increasing need for accurate predictive in vitro assays that reliably detect hepatotoxic drug… read more here.
Keywords: drug induced; hepatotoxicity screening; vitro cell; models drug ... See more keywords
In vitro toxicity model: Upgrades to bridge the gap between preclinical and clinical research
Sign Up to like & getrecommendations! Published in 2019 at "Bosnian Journal of Basic Medical Sciences"
DOI: 10.17305/bjbms.2019.4378
Abstract: The Centers for Disease Control and Prevention (CDC) provides extensive data that indicate our need for drugs to maintain human population health. Despite the substantial availability of drugs on the market, many patients lack specific… read more here.
Keywords: vitro toxicity; toxicity; cell based; drug ... See more keywords
Rapid identification of in vitro cell toxicity using an electrochemical membrane screening platform.
Sign Up to like & getrecommendations! Published in 2023 at "Bioelectrochemistry"
DOI: 10.2139/ssrn.4367220
Abstract: This study compares the performance and output of an electrochemical phospholipid membrane platform against respective in vitro cell-based toxicity testing methods using three toxicants of different biological action (chlorpromazine (CPZ), colchicine (COL) and methyl methanesulphonate… read more here.
Keywords: cell; electrochemical membrane; vitro cell; toxicity ... See more keywords
Evaluation of phytopolyphenols for their gp120-CD4 binding inhibitory properties by in silico molecular modelling & in vitro cell line studies.
Sign Up to like & getrecommendations! Published in 2019 at "Current HIV research"
DOI: 10.2174/1570162x17666190611121627
Abstract: BACKGROUND Lack of effective early-stage HIV-1 inhibitor instigated the need for screening of novel gp120-CD4 binding inhibitor. Polyphenols, a secondary metabolite derived from natural sources are reported to have broad spectrum HIV-1 inhibitory activity. However,… read more here.
Keywords: cell line; line studies; vitro cell; gp120 cd4 ... See more keywords
Functionalized Thick Film Impedance Sensors for Use in In Vitro Cell Culture
Sign Up to like & getrecommendations! Published in 2018 at "Biosensors"
DOI: 10.3390/bios8020037
Abstract: Multi-electrode arrays find application in electrophysiological recordings. The quality of the captured signals depends on the interfacial contact between electrogenic cells and the electronic system. Therefore, it requires reliable low-impedance electrodes. Low-temperature cofired ceramic technology… read more here.
Keywords: gold electrodes; thick film; vitro cell; impedance ... See more keywords