Discovery Phase Agrochemical Predictive Safety Assessment Using High Content In Vitro Data to Estimate an In Vivo Toxicity Point of Departure.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c03094
Abstract: Utilization of in vitro (cellular) techniques, like Cell Painting and transcriptomics, could provide powerful tools for agrochemical candidate sorting and selection in the discovery process. However, using these models generates challenges translating in vitro concentrations… read more here.
Keywords: vivo; vitro; vitro data; content vitro ... See more keywords
Role for antimalarials in the management of COVID-19.
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Rheumatology"
DOI: 10.1097/bor.0000000000000731
Abstract: PURPOSE OF REVIEW The current review highlights recent insights into direct antiviral effects by antimalarials against severe acute respiratory syndrome (SARS)-CoV-2 and other viruses and their potential indirect effects on the host by avoiding exaggerated… read more here.
Keywords: antimalarials management; efficacy; role antimalarials; vitro data ... See more keywords
VitroBert: modeling DILI by pretraining BERT on in vitro data
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cheminformatics"
DOI: 10.1186/s13321-025-01048-7
Abstract: Drug-induced liver injury (DILI) presents a significant challenge due to its complexity, small datasets, and severe class imbalance. While unsupervised pretraining is a common approach to learn molecular representations for downstream tasks, it often lacks… read more here.
Keywords: loss; dili; vitrobert modeling; vitro data ... See more keywords
In vitro data of current therapies for SARS-CoV-2.
Sign Up to like & getrecommendations! Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666200513075430
Abstract: BACKGROUND In December 2019, a new coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has emerged from China causing pneumonia outbreaks first in the Wuhan region and currently worldwide. In the light of the… read more here.
Keywords: current therapies; chemistry; vitro data; therapies sars ... See more keywords
Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.604713
Abstract: Objectives: Improvements in human stem cell-derived cardiomyocyte (hSC-CM) technology have promoted their use for drug testing and disease investigations. Several in silico hSC-CM models have been proposed to augment interpretation of experimental findings through simulations.… read more here.
Keywords: cell derived; silico; drug; stem cell ... See more keywords