Enhancement of in vitro dissolution and pharmacodynamic potential of olanzapine using solid SNEDDS
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-017-0308-x
Abstract: The present research work focused on preparing a solidified lipidic self-nanoemulsifying drug delivery system (S-SNEDDS) by adsorbing liquid SNEDDS onto the surface of inert solid adsorbent (Aerosil-200) to improve the in vitro dissolution of poorly… read more here.
Keywords: dissolution pharmacodynamic; enhancement vitro; olanzapine; vitro dissolution ... See more keywords
Complete in vitro Dissolution of Valbenazine as Either Whole Capsules or Crushed Capsule Contents
Sign Up to like & getrecommendations! Published in 2023 at "CNS Spectrums"
DOI: 10.1017/s1092852923001499
Abstract: Abstract Introduction Tardive dyskinesia (TD) is a persistent and potentially disabling movement disorder associated with exposure to antipsychotics and other dopamine receptor blocking agents. Three valbenazine capsule strengths (40 mg, 60 mg, 80 mg) are… read more here.
Keywords: whole capsules; capsule contents; crushed capsule; capsule ... See more keywords
Polymer Nanogels as Reservoirs To Inhibit Hydrophobic Drug Crystallization.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.8b06393
Abstract: The effects of cross-link density and composition on the loading and in vitro dissolution of the drug phenytoin as amorphous solid dispersions in emulsion polymerized poly( N-isopropylacrylamide) (PNIPAm) and poly( N-isopropylacrylamide- co- N, N-dimethylacrylamide) nanogels… read more here.
Keywords: nanogels reservoirs; inhibit hydrophobic; vitro dissolution; drug ... See more keywords
Characterization, in vitro dissolution, and pharmacokinetics of different batches of efavirenz raw materials
Sign Up to like & getrecommendations! Published in 2021 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2021.1934860
Abstract: Abstract Objective To perform the solid-state characterization and the in vitro-in vivo correlation (IVIVC) of three batches of efavirenz (EFV) active pharmaceutical ingredients. Significance EFV is an effective anti-HIV drug. Due to the poor aqueous… read more here.
Keywords: batches efavirenz; vitro dissolution; efv; characterization vitro ... See more keywords
Predicting the in vitro dissolution rate constant of mineral wool fibers from fiber composition
Sign Up to like & getrecommendations! Published in 2023 at "Inhalation Toxicology"
DOI: 10.1080/08958378.2023.2166167
Abstract: Abstract Objective We developed predictive formulae for the in vitro dissolution rate constant kdis of acid-soluble synthetic vitreous fibers (SVF), paralleling our earlier work with glass wools, which are typically more soluble at neutral pH. Developing… read more here.
Keywords: dissolution rate; rate constant; chemistry; kdis ... See more keywords
Simulation of respiratory tract lining fluid for in vitro dissolution study
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2021.1882991
Abstract: ABSTRACT Introduction: Drug particles inhaled via the respiratory system must first dissolve in the respiratory tract lining fluid (RTLF) that lies on the surfaces of airways and alveoli, so that they are absorbed and have… read more here.
Keywords: respiratory; vitro dissolution; simulated rtlfs; respiratory tract ... See more keywords
In Vitro Dissolution Profile of Antihypertensive Mixture: Comparison between Multivariate Methods and Statistical and Graphical Representation of Different Univariate Spectrophotometric Data.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsac152
Abstract: BACKGROUND Triplixam is a new antihypertensive drug combination consisting of Perindopril, Amlodipine, and Indapamide which have a synergistic mechanism of action in combination with each other. OBJECTIVE Comparative study of different spectrophotometric approaches used for… read more here.
Keywords: mixture; vitro dissolution; graphical representation; value ... See more keywords
In Vitro Dissolution Testing to Assess Pharmaceutical Equivalence of Selected Amoxicillin Products Available in Sri Lanka: A Post-Marketing Study
Sign Up to like & getrecommendations! Published in 2019 at "Dissolution Technologies"
DOI: 10.14227/dt260119p56
Abstract: Guidance documents on biowaivers and published literature, including the biowaiver monograph on amoxicillin, recommend conducting biopharmaceutics classification system (BCS)-based in vitro dissolution studies as a surrogate for in vivo bioequivalence (BE) studies for solid oral… read more here.
Keywords: study; dissolution; amoxicillin; sri lanka ... See more keywords
Arginine Complexes with Simvastatin: Apparent Solubility, In Vitro Dissolution and Solid State Characterization.
Sign Up to like & getrecommendations! Published in 2018 at "Current drug delivery"
DOI: 10.2174/1567201814666170320144259
Abstract: BACKGROUND Categorized as a Biopharmaceutics Classification System (BCS) Class II drugs, statin exhibit low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. This paper describes a de novo approach… read more here.
Keywords: dissolution solid; vitro dissolution; solubility; solubility vitro ... See more keywords
Chemical interactions in composites of gellan gum and bioactive glass: self-crosslinking and in vitro dissolution
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1133374
Abstract: We investigated the interactions between the organic–inorganic phases in composites and the impact on in vitro dissolution. The composite consists of a hydrogel-forming polysaccharide gellan gum (GG, organic phase) and a borosilicate bioactive glass (BAG,… read more here.
Keywords: gellan gum; bioactive glass; bag; glass ... See more keywords
In vitro dissolution/release methods for mucosal delivery systems
Sign Up to like & getrecommendations! Published in 2017 at "ADMET and DMPK"
DOI: 10.5599/admet.5.3.425
Abstract: In vitro dissolution/release tests are an indispensable tool in the drug product development, its quality control and the regulatory approval process. Mucosal drug delivery systems are designed to provide both local and systemic drug action… read more here.
Keywords: delivery; delivery systems; vitro dissolution; dissolution release ... See more keywords