In vitro drug sensitivity (IDS) of patient-derived primary osteosarcoma cells as an early predictor of the clinical outcomes of osteosarcoma patients
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04081-5
Abstract: Purpose Early prediction of clinical response to conventional chemotherapy is a significant factor in determining an overall treatment strategy for osteosarcoma. Methods Cells were extracted from treatment-naïve biopsies from 16 osteosarcoma patients who received a… read more here.
Keywords: clinical outcomes; sensitivity ids; vitro drug; primary osteosarcoma ... See more keywords
Ascarids exposed: a method for in vitro drug exposure and gene expression analysis of anthelmintic naïve Parascaris spp
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology"
DOI: 10.1017/s0031182020000189
Abstract: Abstract Ascarid parasites infect a variety of hosts and regular anthelmintic treatment is recommended for all species. Parascaris spp. is the only ascarid species with widespread anthelmintic resistance, which allows for the study of resistance… read more here.
Keywords: drug exposure; vitro drug; drug; parascaris spp ... See more keywords
A parallelized, perfused 3D triculture model of leukemia for in vitro drug testing of chemotherapeutics
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DOI: 10.1088/1758-5090/ac6a7e
Abstract: Leukemia patients undergo chemotherapy to combat the leukemic cells (LCs) in the bone marrow. During therapy not only the LCs, but also the blood-producing hematopoietic stem and progenitor cells (HSPCs) may be destroyed. Chemotherapeutics targeting… read more here.
Keywords: parallelized perfused; vitro drug; bone marrow; model ... See more keywords
In vitro drug release and antibacterial activity evaluation of silk fibroin coated vancomycin hydrochloride loaded poly (lactic-co-glycolic acid) (PLGA) sustained release microspheres
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomaterials Applications"
DOI: 10.1177/08853282211064098
Abstract: Currently, the treatment of osteomyelitis poses a great challenge to clinical orthopedics. The use of biodegradable materials combined with antibiotics provides a completely new option for the treatment of osteomyelitis. In this study, vancomycin hydrochloride… read more here.
Keywords: loaded microspheres; vancomycin hydrochloride; vitro drug; drug release ... See more keywords
Surfactant Mediated Accelerated and Discriminatory In Vitro Drug Release Method for PLGA Nanoparticles of Poorly Water-Soluble Drug
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DOI: 10.3390/ph15121489
Abstract: In vitro drug release testing is an important quality control tool for formulation development. However, the literature has evidence that poly-lactide-co-glycolide (PLGA)-based formulations show a slower in vitro drug release than a real in vivo… read more here.
Keywords: surfactant mediated; vitro drug; plga; drug release ... See more keywords