Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay
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DOI: 10.1002/em.22083
Abstract: We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric analysis of detergent‐liberated nuclei that are simultaneously stained with propidium iodide and labeled with fluorescent antibodies against p53, γH2AX, and phospho‐histone H3.… read more here.
Keywords: analysis; vitro genotoxicity; genotoxicity assay; interlaboratory evaluation ... See more keywords
The in vitro genotoxicity potency of mixtures of pyrrolizidine alkaloids can be explained by dose addition of the individual mixture components
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22512
Abstract: Plant‐based 1,2‐unsaturated Pyrrolizidine Alkaloids (PAs) are responsible for liver genotoxicity/carcinogenicity following metabolic activation, making them a relevant concern for safety assessment. Due to 21st century toxicology approaches, risk of PAs can be better discerned though… read more here.
Keywords: potency; vitro genotoxicity; genotoxic potency; genotoxicity potency ... See more keywords
In vitro genotoxicity potential investigation of 7 oxy‐PAHs
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DOI: 10.1002/em.22531
Abstract: Air pollutants include many compounds among them oxygenated polycyclic aromatic hydrocarbons (oxy‐PAHs). As they are suspected to generate DNA damage and mutagenicity, an understanding of their mode of action could highlight a carcinogenic potential risk… read more here.
Keywords: vitro genotoxicity; genotoxicity potential; pahs; potential investigation ... See more keywords
In vitro genotoxicity assessment of biosynthesized zinc oxide nanoparticles.
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DOI: 10.1177/07482337231173727
Abstract: There are various studies on the toxicological potentials of conventionally synthesized zinc oxide (ZnO) nanoparticles, which are useful tools for many medical applications. However, knowledge about the biologically synthesized ones is still limited. In this… read more here.
Keywords: biocompatibility tests; zinc; zno nanoparticles; vitro genotoxicity ... See more keywords