In Vitro Inhibition of Human CYP450s 1A2, 2C9, 3A4/5, 2D6 and 2E1 by Grandisin.
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DOI: 10.1055/s-0042-124615
Abstract: Grandisin, a lignan isolated from many species of plants, such as Virola surinamensis, is a potential drug candidate due to its biological properties, highlighted by its antitumor and trypanocidal activities. In this study, the inhibitory… read more here.
Keywords: mechanism based; inhibition human; inhibition; min ... See more keywords
In vitro inhibition of starch digestive enzymes by ultrasound‐assisted extracted polyphenols from Ascophyllum nodosum seaweeds
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DOI: 10.1111/1750-3841.16202
Abstract: Abstract Seaweeds are gaining importance due to their antidiabetic characteristics. This study investigated the inhibitory effects of aqueous Ascophyllum nodosum extracts, obtained by ultrasound‐assisted extraction with different sonication powers (70–90 W/cm2) and subjected to resin… read more here.
Keywords: inhibition; ascophyllum nodosum; vitro inhibition; ultrasound assisted ... See more keywords
In Vitro Inhibition of Phosphodiesterase 3B (PDE 3B) by Anthocyanin-Rich Fruit Juice Extracts and Selected Anthocyanins
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DOI: 10.3390/ijms21186934
Abstract: Phosphodiesterases (PDEs) are essential enzymes for the regulation of pathways mediated by cyclic adenosine monophosphate (cAMP). Secondary plant compounds like anthocyanins (ACs) can inhibit PDE activity and, consequently, may be beneficial for lipid metabolism. This… read more here.
Keywords: juice extracts; pde activity; fruit juice; gae 100 ... See more keywords
In Vitro Inhibition of Replication of Dengue Virus Serotypes 1–4 by siRNAs Bound to Non-Toxic Liposomes
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DOI: 10.3390/v14020339
Abstract: Dengue virus is a ssRNA+ flavivirus, which produces the dengue disease in humans. Currently, no specific treatment exists. siRNAs regulate gene expression and have been used systematically to silence viral genomes; however, they require controlled… read more here.
Keywords: vitro inhibition; sirnas bound; dengue virus; replication ... See more keywords