Translating in vitro ligand bias into in vivo efficacy.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.05.002
Abstract: It is increasingly apparent that ligand structure influences both the efficiency with which G protein-coupled receptors (GPCRs) engage their downstream effectors and the manner in which they are activated. Thus, 'biased' agonists, synthetic ligands whose… read more here.
Keywords: pth1r; vitro ligand; arrestin pathway; efficacy ... See more keywords