Identification of CYP Isozymes Involved in Enantioselective Metabolism of Fipronil in Fish Liver: In Vitro Metabolic Kinetics and Molecular Modeling.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.5241
Abstract: Fipronil has been frequently detected in waterways worldwide at concentrations threatening aquatic organisms, yet metabolic behavior of fipronil enantiomers in aquatic organisms is largely unknown, which is of significance in enantioselective toxicity evaluation. Herein, we… read more here.
Keywords: vitro metabolic; metabolism; isozymes involved; fipronil ... See more keywords
Monocarbonyl curcuminoids as antituberculosis agents with their moderate in‐vitro metabolic stability on human liver microsomes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22754
Abstract: Tuberculosis, an airborne infectious disease, results in a high morbidity and mortality rate. The continuous emergence of TB resistance strains including MDR (multidrug‐resistant tuberculosis), XDR (extensive drug‐resistant tuberculosis), and especially TDR (totally drug‐resistant tuberculosis) is… read more here.
Keywords: vitro metabolic; metabolic stability; monocarbonyl curcuminoids; tuberculosis ... See more keywords
Identification of reactive intermediate formation and bioactivation pathways in Abemaciclib metabolism by LC–MS/MS: in vitro metabolic investigation
Sign Up to like & getrecommendations! Published in 2019 at "Royal Society Open Science"
DOI: 10.1098/rsos.181714
Abstract: Abemaciclib (Verzenio®) is approved as a tyrosine kinase inhibitor (TKI) for breast cancer treatment. In this study, in vitro phase I metabolic profiling of Abemaciclib (ABC) was done using rat liver microsomes (RLMs). We checked… read more here.
Keywords: vitro metabolic; metabolism; identification reactive; formation ... See more keywords
In Vitro Metabolic Study of Four Synthetic Cathinones: 4-MPD, 2-NMC, 4F-PHP and bk-EPDP
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12020115
Abstract: The use of illicit drugs is exceedingly prevalent in society, and several of them can be illegally purchased from the internet. This occurrence is particularly augmented by the rapid emergence of novel psychoactive substances (NPS),… read more here.
Keywords: study four; vitro metabolic; metabolic study; four synthetic ... See more keywords