Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2132426
Abstract: Abstract Non-specific binding in in vitro metabolism systems leads to an underestimation of the true intrinsic metabolic clearance of compounds being studied. Therefore in vitro binding needs to be accounted for when extrapolating in vitro… read more here.
Keywords: specific binding; liver microsomes; different species; vitro metabolism ... See more keywords
Application of In Vitro Metabolism Activation in High-Throughput Screening
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DOI: 10.3390/ijms21218182
Abstract: In vitro methods which incorporate metabolic capability into the assays allow us to assess the activity of metabolites from their parent compounds. These methods can be applied into high-throughput screening (HTS) platforms, thereby increasing the… read more here.
Keywords: metabolism; vitro metabolism; high throughput; activity ... See more keywords
In Vitro Metabolism of Phenylspirodrimanes Derived from the Indoor Fungus Stachybotrys
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DOI: 10.3390/toxins14060395
Abstract: Fungi belonging to the genus Stachybotrys are frequently detected in water-damaged indoor environments, and a potential correlation between emerging health problems of inhabitants of affected housing and the fungi is controversially discussed. Secondary metabolites (i.e.,… read more here.
Keywords: metabolism; phenylspirodrimanes derived; derived indoor; metabolism phenylspirodrimanes ... See more keywords
Study on In Vitro Metabolism and In Vivo Pharmacokinetics of Beauvericin
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DOI: 10.3390/toxins14070477
Abstract: Beauvericin (BEA) is a well-known mycotoxin produced by many fungi, including Beaveria bassiana. The purpose of this study was to evaluate the in vitro distribution and metabolism characteristics as well as the in vivo pharmacokinetic… read more here.
Keywords: study vitro; metabolism; liver microsomes; metabolism vivo ... See more keywords
In vitro metabolism study of a novel P38 kinase inhibitor: in silico predictions, structure elucidation using MS/MS-I.
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DOI: 10.4155/fmc-2017-0126
Abstract: AIM Metabolism study of PH-797804, a promising newly developed drug for treatment of chronic inflammation which inhibits P38 mitogen-activated protein kinase. MATERIALS & METHODS Susceptibility of PH-797804 to metabolism was first investigated using SMARTCyp and… read more here.
Keywords: study novel; metabolism; kinase; vitro metabolism ... See more keywords