In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.70127
Abstract: Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to… read more here.
Keywords: cytotoxicity; vitro modeling; cell; natural killer ... See more keywords
Advances in In Vitro Modeling of Cancer-Stromal Interactions: From Fundamental Insights to Translational Applications.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced materials"
DOI: 10.1002/adma.202512252
Abstract: Accurate in vitro modeling of the tumor microenvironment (TME) is essential for advancing our understanding of cancer biology and for developing effective anti‐cancer therapeutics. Context‐dependent and patient‐specific, the dynamic interactions between cancer cells and stromal… read more here.
Keywords: cancer; vitro modeling; biology; tumor ... See more keywords
Bioengineering Approaches to In Vitro Modeling of Genetic and Acquired Cardiac Diseases
Sign Up to like & getrecommendations! Published in 2025 at "Current Cardiology Reports"
DOI: 10.1007/s11886-025-02218-7
Abstract: This review aims to explore recent advancements in bioengineering approaches used in developing and testing in vitro cardiac disease models. It seeks to find out how these tools can address the limitations of traditional in… read more here.
Keywords: disease; vitro modeling; genetic acquired; approaches vitro ... See more keywords
Optimization of micro-fabricated porous membranes for intestinal epithelial cell culture and in vitro modeling of the human intestinal barrier
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Micromechanics and Microengineering"
DOI: 10.1088/1361-6439/aa96bd
Abstract: In vitro modeling of organs could provide a controlled platform for studying physiological events and has great potential in the field of pharmaceutical development. Here, we describe the characterization of in vitro modeling of the… read more here.
Keywords: porous membranes; modeling human; intestinal barrier; vitro modeling ... See more keywords
3D in vitro modeling of the exocrine pancreatic unit using tomographic volumetric bioprinting
Sign Up to like & getrecommendations! Published in 2024 at "Biofabrication"
DOI: 10.1088/1758-5090/ad6d8d
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, a leading cause of cancer-related deaths globally. Initial lesions of PDAC develop within the exocrine pancreas’ functional units, with tumor progression driven by… read more here.
Keywords: volumetric bioprinting; tomographic volumetric; exocrine pancreas; vitro modeling ... See more keywords
In Vitro Modeling of Skin Barrier Disruption and its Recovery by Ceramide-Based Formulations.
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-021-02154-z
Abstract: Disrupted skin barrier, one of the severe attributes of inflammatory skin diseases, is caused by lower content and pathological changes of lipids in the uppermost skin layer-stratum corneum (SC). Restoring skin barrier with native skin… read more here.
Keywords: vitro models; barrier disruption; skin barrier; barrier ... See more keywords
A Bioreactor for 3D In Vitro Modeling of the Mechanical Stimulation of Osteocytes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.797542
Abstract: The bone is a mechanosensitive organ that is also a common metastatic site for prostate cancer. However, the mechanism by which the tumor interacts with the bone microenvironment to further promote disease progression remains to… read more here.
Keywords: bioreactor; vitro modeling; modeling mechanical; mechanical stimulation ... See more keywords
In vitro Modeling of Embryonal Tumors
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.640633
Abstract: A subset of pediatric tumors affects very young children and are thought to arise during fetal life. A common theme is that these embryonal tumors hijack developmental programs, causing a block in differentiation and, as… read more here.
Keywords: vitro modeling; biology; modeling embryonal; embryonal tumors ... See more keywords
In vitro 3D modeling of colorectal cancer: the pivotal role of the extracellular matrix, stroma and immune modulation
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2025.1545017
Abstract: Colorectal cancer (CRC) is a leading global cancer with high mortality, especially in metastatic cases, with limited therapeutic options. The tumor microenvironment (TME), a network comprising various immune cells, stromal cells and extracellular (ECM) components… read more here.
Keywords: colorectal cancer; cancer; modeling colorectal; role ... See more keywords
Oxygen gradient generator to improve in vitro modeling of ischemic stroke
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1110083
Abstract: Introduction In the core of a brain infarct, perfusion is severely impeded, and neuronal death occurs within minutes. In the penumbra, an area near the core with more remaining perfusion, cells initially remain viable, but… read more here.
Keywords: vitro modeling; oxygen gradient; generator; modeling ischemic ... See more keywords
Case Report: Precision Medicine Target Revealed by In Vitro Modeling of Relapsed, Refractory Acute Lymphoblastic Leukemia From a Child With Neurofibromatosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.851572
Abstract: Children with neurofibromatosis have a higher risk of developing juvenile myelomonocytic leukemia and acute myeloid leukemia, but rarely develop B-cell acute lymphoblastic leukemia (B-ALL). Through in-vitro modeling, a novel NF1 p.L2467 frameshift (fs) mutation identified… read more here.
Keywords: leukemia; vitro modeling; lymphoblastic leukemia; acute lymphoblastic ... See more keywords