Neural In Vitro Models for Studying Substances Acting on the Central Nervous System.
Sign Up to like & getrecommendations! Published in 2020 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2020_367
Abstract: Animal models have been greatly contributing to our understanding of physiology, mechanisms of diseases, and toxicity. Yet, their limitations due to, e.g., interspecies variation are reflected in the high number of drug attrition rates, especially… read more here.
Keywords: nervous system; central nervous; vitro models; neural vitro ... See more keywords
In Vitro Models for Studying Tumor Progression.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0759-6_12
Abstract: Beyond cell proliferation, one of the most outstanding characteristics of the cancerous cells that promotes the tumoral progression is their high capacity to migrate and invade the surrounding healthy tissue. These cellular processes (migration and… read more here.
Keywords: tumor progression; models studying; progression; cell ... See more keywords
In Vitro Models for Studying the Interaction of Neisseria meningitidis with Human Brain Endothelial Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9202-7_10
Abstract: Bacterial meningitis is a serious, life-threatening infection of the central nervous system (CNS). To cause meningitis, bacteria must interact with and penetrate the meningeal blood-cerebrospinal fluid barrier (mB/CSFB), which comprises highly specialized brain endothelial cells.… read more here.
Keywords: brain endothelial; endothelial cells; interaction; neisseria meningitidis ... See more keywords
In Vitro Models of Eye Infection with Neisseria gonorrhoeae.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9496-0_21
Abstract: Prophylaxis with silver nitrate and later antibiotics has significantly reduced the cases of infant blindness from gonococcal infection at birth to the point where it has all but been forgotten in the developed world as… read more here.
Keywords: infection; neisseria gonorrhoeae; models eye; eye infection ... See more keywords
The interrelation of osteoarthritis and diabetes mellitus: considering the potential role of interleukin-10 and in vitro models for further analysis
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation Research"
DOI: 10.1007/s00011-017-1121-8
Abstract: IntroductionToday, not only the existence of an interrelation between obesity/adipositas and osteoarthritis (OA) but also the association of OA and diabetes mellitus (DM) are widely recognized. Nevertheless, shared influence factors facilitating OA development in DM… read more here.
Keywords: diabetes mellitus; role; interrelation osteoarthritis; vitro models ... See more keywords
Impact of diabetes mellitus simulations on bone cell behavior through in vitro models
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-020-01101-5
Abstract: Diabetes mellitus (DM) is related to impaired bone healing and an increased risk of bone fractures. While it is recognized that osteogenic differentiation and the function of osteoblasts are suppressed in DM, the influence of… read more here.
Keywords: bone; mellitus simulations; diabetes mellitus; impact diabetes ... See more keywords
Use of a combination of in vitro models to investigate the impact of chlorpyrifos and inulin on the intestinal microbiota and the permeability of the intestinal mucosa
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-018-2332-4
Abstract: Dietary exposure to the organophosphorothionate pesticide chlorpyrifos (CPF) has been linked to dysbiosis of the gut microbiota. We therefore sought to investigate whether (i) CPF’s impact extends to the intestinal barrier and (ii) the prebiotic… read more here.
Keywords: intestinal mucosa; inulin; vitro models; microbiota ... See more keywords
Engineering in vitro models of hepatofibrogenesis
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DOI: 10.1016/j.addr.2017.05.018
Abstract: ABSTRACT Chronic liver disease is a major cause of morbidity and mortality worldwide marked by chronic inflammation and fibrosis/scarring, resulting in end‐stage liver disease and its complications. Hepatic stellate cells (HSCs) are a dominant contributor… read more here.
Keywords: engineering vitro; models hepatofibrogenesis; liver; vitro ... See more keywords
Patient-Derived In Vitro Models of Microglial Function and Synaptic Engulfment in Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Biological psychiatry"
DOI: 10.1016/j.biopsych.2022.01.004
Abstract: Multiple lines of evidence implicate dysregulated microglia-mediated synaptic pruning in the pathophysiology of schizophrenia. In vitro human cellular studies represent a promising means of pursuing this hypothesis, complementing efforts with animal models and postmortem human data… read more here.
Keywords: vitro models; derived vitro; schizophrenia; models microglial ... See more keywords
CELLector: Genomics-Guided Selection of Cancer In Vitro Models.
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DOI: 10.1016/j.cels.2020.04.007
Abstract: Selecting appropriate cancer models is a key prerequisite for maximizing translational potential and clinical relevance of in vitro oncology studies. We developed CELLector: an R package and R Shiny application allowing researchers to select the most… read more here.
Keywords: cellector; selection; cancer; cell ... See more keywords
Refining in vitro models for nanomaterial exposure to cells and tissues
Sign Up to like & getrecommendations! Published in 2018 at "NanoImpact"
DOI: 10.1016/j.impact.2018.02.008
Abstract: Abstract With the increasing use of nanomaterials (NMs) in a variety of commercial and medical applications, there is a parallel increase in concern related to unintentional exposure. This leads to a pressing need for appropriate… read more here.
Keywords: exposure; refining vitro; exposure cells; cells tissues ... See more keywords