Characterization of reactive intermediates formation in dacomitinib metabolism and bioactivation pathways elucidation by LC-MS/MS: in vitro phase I metabolic investigation
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DOI: 10.1039/c8ra06709k
Abstract: Dacomitinib (DCB) is a second generation irreversible tyrosine kinase inhibitor (TKI) that is claimed to overcome the disadvantages of the resistance developed by the first line epidermal growth factor receptor (EGFR) TKIs. In the current… read more here.
Keywords: vitro phase; characterization reactive; bioactivation; reactive intermediates ... See more keywords
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds
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DOI: 10.1080/00498254.2022.2140315
Abstract: Abstract Aggregates of the protein α-synuclein are associated with pathophysiology of Parkinson’s disease and are present in Lewy Bodies found in the brains of Parkinson’s patients. We previously demonstrated that bifunctional compounds composed of caffeine… read more here.
Keywords: pet probes; phase; vitro phase; phase kinetics ... See more keywords