An in silico–in vitro pipeline for drug cardiotoxicity screening identifies ionic pro‐arrhythmia mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15915
Abstract: Before advancing to clinical trials, new drugs are screened for their pro‐arrhythmic potential using a method that is overly conservative and provides limited mechanistic insight. The shortcomings of this approach can lead to the mis‐classification… read more here.
Keywords: pipeline drug; vitro pipeline; drug cardiotoxicity; screening identifies ... See more keywords
Commentary: An In Silico – In Vitro Pipeline Identifying an HLA-A*02:01+ KRAS G12V+ Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.523906
Abstract: In their original research (1), the authors were looking for a potential KRAS epitope for use in targeted cancer immunotherapy in the form of an HLA-presented peptide that would have the following three properties: i)… read more here.
Keywords: commentary silico; pipeline identifying; vitro pipeline; silico vitro ... See more keywords