Promiscuity of in vitro secondary pharmacology assays and implications for lead optimization strategies.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01625
Abstract: We conducted an analysis on screening data generated from 1445 compounds against a panel of 130 enzymes, ion channels and receptors to assess secondary pharmacological risks. Hit rates of these targets as well as physicochemical… read more here.
Keywords: secondary pharmacology; assays implications; pharmacology assays; pharmacology ... See more keywords