Inverse In Vitro Selection Enables Comprehensive Analysis of Cross‐Chiral L‐Aptamer Interactions
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200520
Abstract: Aptamers composed of mirror‐image L‐(deoxy)ribose nucleic acids, referred to as L‐aptamers, are a promising class of RNA‐binding reagents. Yet, the selectivity of cross‐chiral interactions between L‐aptamers and their RNA targets remain poorly characterized, limiting the… read more here.
Keywords: vitro selection; cross chiral; aptamer; inverse vitro ... See more keywords
Toward Unravelling the Genetic Determinism of the Acquisition of Salt and Osmotic Stress Tolerance Through In Vitro Selection in Medicago truncatula.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8633-0_19
Abstract: Changes in global climate and the nonstop increase in demographic pressure have provoked a stronger demand for agronomic resources at a time where land suitable for agriculture is becoming a rare commodity. They have also… read more here.
Keywords: tolerance; vitro selection; osmotic stress; stress ... See more keywords
Development of a Cyclic, Cell Penetrating Peptide Compatible with In Vitro Selection Strategies.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00680
Abstract: A key limitation for the development of peptides as therapeutics is their lack of cell permeability. Recent work has shown that short, arginine-rich macrocyclic peptides containing hydrophobic amino acids are able to penetrate cells and… read more here.
Keywords: cell; cyclic cell; development; cell penetrating ... See more keywords
A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c8cc10192b
Abstract: Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized… read more here.
Keywords: stapled peptide; vitro selection; mrna display; strategy vitro ... See more keywords
REVERSE: a user-friendly web server for analyzing next-generation sequencing data from in vitro selection/evolution experiments
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1101/2022.03.21.485196
Abstract: Next-generation sequencing (NGS) enables the identification of functional nucleic acid sequences from in vitro selection/evolution experiments and illuminates the evolutionary process at single nucleotide resolution. However, analyzing the vast output from NGS can be daunting,… read more here.
Keywords: evolution experiments; selection evolution; next generation; vitro selection ... See more keywords
In vitro selection of potential immunomodulatory multispecies lactic acid bacteria in broilers
Sign Up to like & getrecommendations! Published in 2018 at "Indian Journal of Animal Research"
DOI: 10.18805/ijar.b-3547
Abstract: Modulation of host immunity is one of the proposed benefits of the consumption of probiotics. In this study a total of 26 lactic acid bacteria belonging to eight different species were isolated from chicken gut.… read more here.
Keywords: selection potential; vitro selection; expression; acid bacteria ... See more keywords
Key Aspects of Nucleic Acid Library Design for in Vitro Selection
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DOI: 10.3390/ijms19020470
Abstract: Nucleic acid aptamers capable of selectively recognizing their target molecules have nowadays been established as powerful and tunable tools for biospecific applications, be it therapeutics, drug delivery systems or biosensors. It is now generally acknowledged… read more here.
Keywords: library design; vitro selection; selection; nucleic acid ... See more keywords
In Vitro Selection of Lactobacillus and Bifidobacterium Probiotic Strains for the Management of Oral Pathobiont Infections Associated to Systemic Diseases
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DOI: 10.3390/ijms232416163
Abstract: The human oral pathobionts Aggregatibacter actinomycetemcomitans, Streptococcus mitis and Streptococcus mutans, in dysbiosis-promoting conditions, lead to oral infections, which also represent a threat to human systemic health. This scenario may be worsened by antibiotic misuse,… read more here.
Keywords: bifidobacterium probiotic; probiotic strains; bifidobacterium; lactobacillus bifidobacterium ... See more keywords