In Vitro and In Silico Analysis of Ascorbic Acid Towards Lanosterol 14-α-Demethylase Enzyme of Fluconazole-Resistant Candida albicans
Sign Up to like & getrecommendations! Published in 2020 at "Current Microbiology"
DOI: 10.1007/s00284-020-02269-9
Abstract: Antibiotic resistance is one of the major concerns and the biggest threats to the world population. The incidents of antibiotic resistance in Candida spp. were frequently recorded. In the present investigation, antifungal potential of ascorbic… read more here.
Keywords: analysis; silico analysis; ascorbic acid; vitro silico ... See more keywords
An Integrated In Vitro–In Silico Approach for Silver Nanoparticle Dosimetry in Cell Cultures
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-020-02449-5
Abstract: Potential human and environmental hazards resulting from the exposure of living organisms to silver nanoparticles (Ag NPs) have been the subject of intensive discussion in the last decade. Despite the growing use of Ag NPs… read more here.
Keywords: silver; vitro silico; dosimetry; approach ... See more keywords
Combined in Vitro-in Silico Approach to Predict Deposition and Pharmacokinetics of Budesonide Dry Powder Inhalers.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical research"
DOI: 10.1007/s11095-020-02924-7
Abstract: PURPOSE A combined in vitro - in silico methodology was designed to estimate pharmacokinetics of budesonide delivered via dry powder inhaler. METHODS Particle size distributions from three budesonide DPIs, measured with a Next Generation Impactor… read more here.
Keywords: dry powder; combined vitro; deposition; vitro silico ... See more keywords
Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment
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DOI: 10.1007/s13659-017-0125-y
Abstract: The antiparasitic activity and preliminary in vitro and in silico drug metabolism and pharmacokinetic (DMPK) assessment of six isomeric sesquiterpenes (1–6), isolated from the Cameroonian spice Scleria striatinux De Wild (Cyperaceae) is reported. The study… read more here.
Keywords: dmpk; vitro silico; dmpk assessment; assessment ... See more keywords
In vitro and in silico studies of naphthoquinones and peptidomimetics toward Plasmodium falciparum plasmepsin V.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.07.002
Abstract: Plasmodium proteases play both regulatory and effector roles in essential biological processes in this important pathogen and have long been investigated as drug targets. Plasmepsin V from P. falciparum (PfPMV) is an essential protease that processes… read more here.
Keywords: naphthoquinones peptidomimetics; studies naphthoquinones; silico studies; vitro silico ... See more keywords
In-vitro and in-silico characterization of zein fiber incorporating cuminaldehyde
Sign Up to like & getrecommendations! Published in 2021 at "Food and Bioproducts Processing"
DOI: 10.1016/j.fbp.2021.05.003
Abstract: Abstract The zein solutions containing different concentrations of cuminaldehyde (5%, 10%, and 20%, w/w) were electrospun. The morphology and average diameter of fibers were evaluated by scanning electron microscopy and the optimized fiber (20% cuminaldehyde)… read more here.
Keywords: vitro silico; spectroscopy; cuminaldehyde; silico characterization ... See more keywords
In vitro and in silico investigation of anthocyanin derivatives as soluble epoxide hydrolase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.02.061
Abstract: Anthocyanin derivatives are well-known secondary constituents contained in fruits. The inhibitory activity of anthocyanin derivatives toward soluble epoxide hydrolase (sEH) was tested for potential applications in the treatment of cardiovascular diseases. Anthocyanin derivatives 1-5 showed… read more here.
Keywords: soluble epoxide; anthocyanin derivatives; epoxide hydrolase; anthocyanin ... See more keywords
In vitro and in silico assessment of DNA interaction, topoisomerase I and II inhibition properties of chrysosplenetin.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.049
Abstract: Chrysosplenetin is a methoxyflavone with reported anti-cancer effect. We tested its cytotoxic effect on the MCF-7 breast cancer cell line, and determined its effect on DNA intercalation and on the activity of topoisomerases I and… read more here.
Keywords: topoisomerase inhibition; dna; vitro silico; topoisomerase ... See more keywords
In vitro and in silico testing of partially and fully bioresorbable vascular scaffold.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of biomechanics"
DOI: 10.1016/j.jbiomech.2020.110158
Abstract: Coronary artery disease (CAD), one of the leading causes of death globally, occurs due to the growth of atherosclerotic plaques in the coronary arteries, causing lesions which restrict the flow of blood to the myocardium.… read more here.
Keywords: silico testing; vitro silico; testing partially; fully bioresorbable ... See more keywords
In vitro and in silico modeling of endovascular stroke treatments for acute ischemic stroke.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomechanics"
DOI: 10.1016/j.jbiomech.2021.110693
Abstract: Acute ischemic stroke occurs when a thrombus obstructs a cerebral artery, leading to sub-optimal blood perfusion to brain tissue. A recently developed, preventive treatment is the endovascular stroke treatment (EVT), which is a minimally invasive… read more here.
Keywords: endovascular stroke; ischemic stroke; silico modeling; vitro silico ... See more keywords
Insights into DPI sensitivity to humidity: An integrated in-vitro-in-silico risk-assessment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.05.047
Abstract: Abstract Dry powder inhalers (DPIs) are known to be sensitive to humidity. Erroneous storage of these products by patients in high humidity environments, could present a potential risk. Therefore, an in-vitro-in-silico approach was utilized to… read more here.
Keywords: vitro silico; sensitivity humidity; humidity; risk ... See more keywords