Key Challenges for In vitro Testing of Tobacco Products for Regulatory Applications: Recommendations for Dosimetry.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3344
Abstract: The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to develop recommendations for optimal scientific and technical approaches for conducting in vitro assays to assess potential toxicity within and across tobacco… read more here.
Keywords: tobacco products; tobacco; key challenges; challenges vitro ... See more keywords
Biorelevant two-stage in vitro testing for rDCS classification and in PBPK modelling - Case example ritonavir.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.04.023
Abstract: Biorelevant two-stage in vitro testing is increasingly used as a tool for various applications in drug development. Three important applications of two-stage in vitro testing are the classification of weakly basic drug compounds as part… read more here.
Keywords: classification; two stage; drug; stage vitro ... See more keywords
Advanced In Vitro Testing Strategies and Models of the Intestine for Nanosafety Research.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00079
Abstract: There is growing concern about the potential adverse effects of oral exposure to engineered nanomaterials (ENM). Recent years have witnessed major developments in and advancement of intestinal in vitro models for nanosafety evaluation. The present… read more here.
Keywords: research; advanced vitro; testing strategies; nanosafety research ... See more keywords
Preparation, Characterization, and In Vitro Testing of Nanoclay Antimicrobial Activities and Elicitor Capacity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b00049
Abstract: Clay-based nanocomposites (nanoclays) are interesting systems to hold a wide type of active substances with a wide field of industrial applications. Bentonite-chitosan nanoclay was obtained via cationic exchange of natural bentonite (Bent) with an aqueous… read more here.
Keywords: nanoclay antimicrobial; testing nanoclay; characterization vitro; preparation characterization ... See more keywords
Defibrillator-Heart Pump: An Implantable Ventricular Assist Device With Integrated Defibrillator Component—The First In Vitro Testing
Sign Up to like & getrecommendations! Published in 2019 at "Surgical Innovation"
DOI: 10.1177/1553350619862994
Abstract: Left ventricular assist devices (LVADs) are an important therapeutic option for patients with end-stage heart failure waiting for heart transplantation or in older patients as definite therapy for heart failure. Interestingly, about 62% of patients… read more here.
Keywords: heart; first vitro; heart failure; defibrillator ... See more keywords
Characterization and in vitro testing of newly isolated lytic bacteriophages for the biocontrol of Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2022 at "Future microbiology"
DOI: 10.2217/fmb-2021-0027
Abstract: Aim: Two lytic phages were isolated using P. aeruginosa DSM19880 as host and fully characterized. Materials & methods: Phages were characterized physicochemically, biologically and genomically. Results & conclusion: Host range analysis revealed that the phages… read more here.
Keywords: isolated lytic; newly isolated; vitro testing; testing newly ... See more keywords
In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2017 at "Biomedicines"
DOI: 10.3390/biomedicines5030040
Abstract: The increasing occurrence of antibiotic-resistant Staphylococcus (S.) aureus tremendously limits the antibiotic-based treatment options; therefore, an open discussion of alternative treatment strategies is urgently needed. The use of naturally derived materials might become a more… read more here.
Keywords: staphylococcus aureus; testing crude; plant; ability ... See more keywords
Liposome Formulation and In Vitro Testing in Non-Physiological Conditions Addressed to Ex Vivo Kidney Perfusion
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147999
Abstract: This work focuses on formulating liposomes to be used in isolated kidney dynamic machine perfusion in hypothermic conditions as drug delivery systems to improve preservation of transplantable organs. The need mainly arises from use of… read more here.
Keywords: liposome formulation; kidney; perfusion; vitro testing ... See more keywords
Characterization of Promising Cytotoxic Metabolites from Tabebuia guayacan Hemsl.: Computational Prediction and In Vitro Testing
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DOI: 10.3390/plants11070888
Abstract: Genus Tabebuia is famous for its traditional uses and valuable phytoconstituents. Our previous investigation of Tabebuia species noted the promising anticancer activity of T. guayacan Hemsl. leaves extract, however, the mechanism underlying the observed anticancer… read more here.
Keywords: guayacan hemsl; activity; vitro testing; kcal mol ... See more keywords
Repurposing Lansoprazole and Posaconazole to treat leishmaniasis: Integration of in vitro testing, pharmacological corroboration, and mechanisms of action
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Food and Drug Analysis"
DOI: 10.38212/2224-6614.3394
Abstract: Leishmaniasis remains a serious public health problem in many tropical regions of the world. Among neglected tropical diseases, the mortality rate of leishmaniasis is second only to malaria. All currently approved therapeutics have toxic side… read more here.
Keywords: repurposing lansoprazole; action; lansoprazole posaconazole; leishmaniasis ... See more keywords