In Vitro and In Vivo Antimicrobial Activity of Antibiotic-Conjugated Carriers with Rapid pH-Responsive Release Kinetics.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900247
Abstract: Two representative antibiotics, cephradine (CP) and moxifloxacin (MX), are covalently conjugated with a β-cyclodextrin (β-CD)-based carrier via pH-responsive 1-methyl-2-(2'-carboxyethyl) maleic acid amide (MCM) linkers with excellent conjugation efficiency via simple mixing. At pH 5.5, 90%… read more here.
Keywords: vitro vivo; antimicrobial activity; activity antibiotic; vivo antimicrobial ... See more keywords
Guanylated Hyperbranched Polylysines with High In Vitro and In Vivo Antifungal Activity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201091
Abstract: With the rapid growth of fungal infections and the emergence of multi‐drug resistant (MDR) fungal strains, new antifungals with novel mechanisms are a pressing need to tackle this emerging health problem. Herein it is reported… read more here.
Keywords: vitro vivo; high vitro; guanylated hyperbranched; hyperbranched polylysines ... See more keywords
Enzymatically Crosslinked Collagen as a Versatile Matrix for In Vitro and In Vivo Co‐Engineering of Blood and Lymphatic Vasculature
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202209476
Abstract: Adequate vascularization is required for the successful translation of many in vitro engineered tissues. This study presents a novel collagen derivative that harbors multiple recognition peptides for orthogonal enzymatic crosslinking based on sortase A (SrtA)… read more here.
Keywords: vitro vivo; crosslinking; collagen; blood ... See more keywords
Ellagic acid as a potent anti-cancer drug: A comprehensive review on in vitro, in vivo, in silico and drug delivery studies.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2288
Abstract: Ellagic acid as a polyphenol or micronutrient which can be naturally found in different vegetables and fruits, have gained considerable attention for cancer therapy due to considerable biological activities and different molecular targets. Ellagic acid… read more here.
Keywords: cancer; vitro vivo; drug; delivery ... See more keywords
An oleanolic acid derivative, K73‐03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11866
Abstract: Oleanolic acid (OA) and its derivatives show potent anticancer function. Pancreatic cancer (PC) is the fourth core motive of cancer‐related deaths worldwide. Epidermal growth factor receptor (EGFR) has been implicated in PC and has been… read more here.
Keywords: vitro vivo; pancreatic cancer; k73; cancer ... See more keywords
A Green Synthesis of Carbene‐Metal‐Amides (CMAs) and Carboline‐Derived CMAs with Potent in vitro and ex vivo Anticancer Activity
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200135
Abstract: The modularity and ease of synthesis of carbene‐metal‐amide (CMA) complexes based on the coinage metals (Au, Ag, Cu) and N‐heterocyclic carbenes (NHCs) as ancillary ligands pave the way for the expansion of their applications beyond… read more here.
Keywords: synthesis carbene; vitro vivo; carbene metal; synthesis ... See more keywords
Update on Metabolism of Abemaciclib: In Silico, In vitro and In vivo Metabolite Identification and Characterization using High Resolution Mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2725
Abstract: Abemaciclib is approved by US Food and Drug Administration in 2015 to have an advanced treatment for metastatic breast cancer. Identification and characterization of limited numbers of abemaciclib metabolites have been reported in the literature.… read more here.
Keywords: high resolution; vitro vivo; mass; using high ... See more keywords
In vitro and in vivo assessments of the genotoxic potential of 3‐chloroallyl alcohol
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22515
Abstract: 3‐Chloroallyl alcohol (3‐CAA) can be found in the environment following the application of plant protection products. 3‐CAA is formed in groundwater following the injection of 1,3‐dichloropropene, a fumigant used to control nematodes. 3‐CAA is also… read more here.
Keywords: vitro vivo; caa; chloroallyl alcohol;
Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose
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DOI: 10.1002/em.22521
Abstract: Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Traditional genotoxicity assays (i.e., mutagenicity, clastogenicity, and aneugenicity) have been limited to dichotomous hazard classification, while other toxicity endpoints are assessed through… read more here.
Keywords: genotoxicity data; genotoxicity; vitro vivo; vivo extrapolation ... See more keywords
A Comparison of the chemical sensitivities between in vitro and in vivo propagated juvenile freshwater mussels: Implications for standard toxicity testing.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4270
Abstract: Unionid mussels are ecologically important and are globally imperiled. Toxicants contribute to mussel declines, and toxicity tests using juvenile mussels-a sensitive life stage-are valuable in determining thresholds used to set water quality criteria. In vitro… read more here.
Keywords: toxicity testing; vitro vivo; toxicity; vivo propagated ... See more keywords
PTEN improve renal fibrosis in vitro and in vivo through inhibiting FAK/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29057
Abstract: Renal fibrosis, the ultimate common pathway of progressive nephropathy, is characterized by excess accumulation and deposition of extracellular matrix (ECM) within the renal interstitium and glomeruli, finally resulting in end‐stage kidney failure. TGFβ1 is not… read more here.
Keywords: fibrosis; vitro vivo; inhibiting fak; fak akt ... See more keywords