Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14494
Abstract: Uncoupling protein‐3 (UCP3) is a mitochondrial transmembrane protein highly expressed in the muscle that has been implicated in regulating the efficiency of mitochondrial oxidative phosphorylation. Increasing UCP3 expression in skeletal muscle enhances proton leak across… read more here.
Keywords: overexpression ucp3; vivo; muscle; efficiency ... See more keywords
Multifunctional Glyco-Nanofibers: siRNA Induced Supermolecular Assembly for Codelivery In Vivo
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DOI: 10.1002/adfm.201703083
Abstract: Targeted codelivery and controlled release of drug/siRNA (small interfering RNA) in a safe and effective vehicle hold great promises for overcoming drug resistance and optimal efficacy in cancer treatment; however, rational design and preparation of… read more here.
Keywords: glyco nanofibers; supermolecular assembly; codelivery; vivo ... See more keywords
Ultrasensitive NIR‐SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201700870
Abstract: Immunotargeting ability of antibodies may show significant difference between in vitro and in vivo. To select antibody leads with high affinity and specificity, it is necessary to perform in vivo validation of antibody candidates following… read more here.
Keywords: validation; vivo; nir serrs; antibody ... See more keywords
Using Ultrafast Responsive Phosphorescent Nanoprobe to Visualize Elevated Peroxynitrite In Vitro and In Vivo via Ratiometric and Time‐Resolved Photoluminescence Imaging
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201800309
Abstract: Peroxynitrite (ONOO- ), a potent biological oxidant, which has a short half-life in physiological conditions, is related to many diseases. Accurate peroxynitrite determination with superior selectivity and sensitivity is important for understanding biological roles of… read more here.
Keywords: photoluminescence imaging; time resolved; vivo via; vivo ... See more keywords
A Facile, Protein‐Derived Supramolecular Theranostic Strategy for Multimodal‐Imaging‐Guided Photodynamic and Photothermal Immunotherapy In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202109111
Abstract: Theranostic systems that permit both diagnosis and treatment in vivo are highly appealing means by which to meet the demands of precision medicine. However, most such systems remain subject to issues related to complex molecular… read more here.
Keywords: vivo; supramolecular theranostic; strategy; photodynamic photothermal ... See more keywords
An Implantable Magnetic Vascular Scaffold for Circulating Tumor Cell Removal In Vivo
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DOI: 10.1002/adma.202207870
Abstract: An integrated trapped device (ITD) capable of removal of circulating tumor cells (CTCs) can assuage or even prevent metastasis. However, adhesion repertoires are ordinarily neglected in the design of ITDs, possibly leading to the omission… read more here.
Keywords: circulating tumor; vascular; itd; vivo ... See more keywords
Engineering and Development of a Tissue Model for the Evaluation of Microneedle Penetration Ability, Drug Diffusion, Photothermal Activity, and Ultrasound Imaging: A Promising Surrogate to Ex Vivo and In Vivo Tissues
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202210034
Abstract: Driven by regulatory authorities and the ever‐growing demands from industry, various artificial tissue models have been developed. Nevertheless, there is no model to date that is capable of mimicking the biomechanical properties of the skin… read more here.
Keywords: diffusion; vivo; evaluation microneedle; model ... See more keywords
Multistage Delivery Nanoparticle Facilitates Efficient CRISPR/dCas9 Activation and Tumor Growth Suppression In Vivo
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201801423
Abstract: Abstract CRISPR/dCas9 systems can precisely control endogenous gene expression without interrupting host genomic sequence and have provided a novel and feasible strategy for the treatment of cancers at the transcriptional level. However, development of CRISPR/dCas9‐based… read more here.
Keywords: crispr; vivo; delivery; crispr dcas9 ... See more keywords
Development of a Non‐Coding‐RNA‐based EMT/CSC Inhibitory Nanomedicine for In Vivo Treatment and Monitoring of HCC
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DOI: 10.1002/advs.201801885
Abstract: Abstract The objective of this study is to improve the overall prognosis of patients with hepatocellular carcinoma (HCC); therefore, new therapeutic methods that can be used in vivo are urgently needed. In this study, the… read more here.
Keywords: hcc; vivo; mir 125b; treatment ... See more keywords
A Cell‐Free Platform Based on Nisin Biosynthesis for Discovering Novel Lanthipeptides and Guiding their Overproduction In Vivo
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DOI: 10.1002/advs.202001616
Abstract: Abstract Lanthipeptides have extensive therapeutic and industrial applications. However, because many are bactericidal, traditional in vivo platforms are limited in their capacity to discover and mass produce novel lanthipeptides as bacterial organisms are often critical… read more here.
Keywords: overproduction; vivo; cell free; platform ... See more keywords
Bioresorbable Nanostructured Chemical Sensor for Monitoring of pH Level In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202062
Abstract: Here, the authors report on the manufacturing and in vivo assessment of a bioresorbable nanostructured pH sensor. The sensor consists of a micrometer‐thick porous silica membrane conformably coated layer‐by‐layer with a nanometer‐thick multilayer stack of… read more here.
Keywords: nanostructured chemical; vivo; level; bioresorbable nanostructured ... See more keywords