Preparation, Physicochemical Characterization and In Vitro and In Vivo Activity Against Heligmosomoides polygyrus of Novel Oral Formulations of Albendazole and Mebendazole
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.xphs.2020.02.002
Abstract: Abstract Albendazole (ABZ) and mebendazole (MBZ) are the 2 most commonly used drugs in the treatment of soil-transmitted helminth infections in humans, but their performance is hampered by low solubility and physicochemical properties. We developed… read more here.
Keywords: vivo activity; mbz; activity; abz ... See more keywords
Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01533
Abstract: Society urgently needs new, effective medicines for the treatment of tuberculosis. To kick-start the required hit-to-lead campaigns, the libraries of pharmaceutical companies have recently been evaluated for starting points. The GlaxoSmithKline (GSK) library yielded many… read more here.
Keywords: vivo activity; chemistry; series; tuberculosis ... See more keywords
In vitro and in vivo activity of fosfomycin alone and in combination with rifampin and tigecycline against Gram-positive cocci isolated from surgical wound infections.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.000649
Abstract: Complicated skin and soft tissue infections constitute a heterogeneous group of severe disorders, with surgical site infections being the most common hospital-acquired ones. The aim of our study was to investigate the synergistic and bactericidal… read more here.
Keywords: vivo activity; alone combination; combination rifampin; vitro vivo ... See more keywords
In Vitro and In Vivo Activity of Peptidomimetic Compounds That Target the Periodontal Pathogen Porphyromonas gingivalis
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00400-18
Abstract: ABSTRACT The interaction of the periodontal pathogen Porphyromonas gingivalis with oral streptococci is important for initial colonization of the oral cavity by P. gingivalis and is mediated by a discrete motif of the streptococcal antigen… read more here.
Keywords: vivo activity; vitro vivo; pathogen porphyromonas; porphyromonas gingivalis ... See more keywords
The Novel Arylamidine T-2307 Demonstrates In Vitro and In Vivo Activity against Candida auris
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DOI: 10.1128/aac.02198-19
Abstract: The in vitro and in vivo activity of the arylamidine T-2307 against Candida auris was evaluated. T-2307 demonstrated in vitro activity (MIC ranges ≤ 0.008 to 0.015 μg/ml at 50% inhibition; 0.125 to >4 μg/ml at 100% inhibition). ABSTRACT… read more here.
Keywords: arylamidine 2307; vivo activity; candida auris; activity ... See more keywords
Abstract A16: The in vitro and in vivo activity of the pyrrolomycin marinopyrrole RL71 alone and combined with temsirolimus (TEM) in MYCN-amplified neuroblastoma (NB)
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca17-a16
Abstract: Introduction: We previously reported a series of novel marinopyrroles as Mcl-1/Bcl-2 inhibitors for potential anticancer activity. The marinopyrrole agents have not been studied in pediatric tumors including neuroblastoma (NB). Temsirolimus (TEM) is an mTOR inhibitor… read more here.
Keywords: vivo activity; cell; rl71; tem ... See more keywords