Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their In Vivo Adjuvant Activity
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DOI: 10.1021/acs.jmedchem.1c00644
Abstract: We report on the design, synthesis, and biological evaluation of a series of nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) desmuramylpeptide agonists with improved in vitro and in vivo adjuvant properties. We identified two promising compounds: 68,… read more here.
Keywords: fine tuning; vivo adjuvant; adjuvant activity; structural fine ... See more keywords
Lipidation of NOD2 Agonists with Adamantane and Stearoyl Moieties Differentially Regulates Their In Vivo Adjuvant Activity
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DOI: 10.3390/pharmaceutics14122755
Abstract: NOD2 is an innate immune receptor that constitutes an important target for the development of small molecule immunopotentiators with great potential to be used as vaccine adjuvants. We report here the results of an in… read more here.
Keywords: nod2 agonists; immune response; adjuvant activity; lipidation nod2 ... See more keywords