Discovery of new 2-phenyl-1H-benzo[d]imidazole core-based potent α-glucosidase inhibitors: Synthesis, kinetic study, molecular docking, and in vivo anti-hyperglycemic evaluation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105423
Abstract: In the present study, a series of 2-phenyl-1H-benzo[d]imidazole-based α-glucosidase inhibitors were synthesized and evaluated for their in vitro and in vivo anti-diabetic potential. Screening of an in-house library revealed a moderated α-glucosidase inhibitor, 6a with… read more here.
Keywords: phenyl benzo; vivo anti; glucosidase inhibitors; study ... See more keywords
Ex vivo anti-inflammatory effects of probiotics for periodontal health
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Oral Microbiology"
DOI: 10.1080/20002297.2018.1502027
Abstract: ABSTRACT Background: Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in gingivitis. Objective: To evaluate the effects of potential probiotic strains on inflammatory mediators involved in early gingivitis using an… read more here.
Keywords: anti inflammatory; lpc g110; vivo anti; inflammatory mediators ... See more keywords
Polycaprolactone nanofibres loaded with 20(S)-protopanaxadiol for in vitro and in vivo anti-tumour activity study
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DOI: 10.1098/rsos.180137
Abstract: In this work, 20(S)-protopanaxadiol (PPD)-loaded polycaprolactone (PCL) nanofibres were successfully fabricated by the electrospinning technique using Tween 80 as a solubilizer. Firstly, smooth and continuous nanofibres were collected using suitable solvents and appropriate spinning conditions.… read more here.
Keywords: tumour activity; vitro vivo; vivo anti; drug ... See more keywords
In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents
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DOI: 10.1186/s12936-020-03552-7
Abstract: Background Kniphofia foliosa is a flamboyant robust perennial herb which has dense clumps and tick upright rhizomes with leaves at the base. In Ethiopia, it has several vernacular names including Abelbila , Ashenda , Amelmela… read more here.
Keywords: hydroalcoholic extract; vivo anti; anti malarial; extract ... See more keywords
Nanoincorporation of Plumbagin in Micelles Increase Its in Vivo Anti-Plasmodial Properties
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Parasitology"
DOI: 10.18502/ijpa.v17i2.9538
Abstract: Background: The application of plumbagin (PLN), with a wide use in pharmaceutical science, is limited due to its low water solubility and poor bioavailability. Micelles can encapsulate hydrophobic drugs due to their hydrophobic core. The… read more here.
Keywords: anti plasmodial; vivo anti; drug; plumbagin ... See more keywords
In vitro and in vivo anti-lung cancer activity of emodin: A RNA-seq transcriptome analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220921120314
Abstract: Emodin is a natural anthraquinone extract of Chinese medicinal herbs. Several studies demonstrated the antitumor activity of this extract, particularly for lung cancer. However, the mode of action of emodin remains obscure. In this study… read more here.
Keywords: lung cancer; vitro vivo; anti lung; vivo anti ... See more keywords
FORMULATION, EVALUATION, AND IN VIVO ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITIES OF MORINGA GRANULES
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2021v13i3.40478
Abstract: Objective: Consumption of crude natural products like plants and herbs for mitigation or treatment of illnesses usually accompanied with inconsistent therapeutic effects because of poor solubility and low bioavailability of active phytochemical(s) in addition to… read more here.
Keywords: vivo anti; moringa granules; anti arthritic; anti inflammatory ... See more keywords
In vitro and in vivo anti-inflammatory, antibacterial and pharmacokinetic properties of baicalein
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DOI: 10.24099/vet.arhiv.1502
Abstract: Baicalein is a bioactive flavone originally isolated from the roots of Scutellaria baicalensis, Scutellariala teriflora and Oroxylum indicum. The in vitro and in vivo anti-inflammatory and antibacterial properties of baicalein and pharmacokinetics after its single… read more here.
Keywords: properties baicalein; vitro vivo; inflammatory antibacterial; vivo anti ... See more keywords
In vitro and In vivo Anti-inflammatory Activities of Mesua ferrea Linn
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DOI: 10.25258/phyto.v10i03.11940
Abstract: Objective: Mesuaferrea L is a medicinal plant belongs to the family Clusiace, it is extensively used in folk medicine for treatment of chronic inflammatory diseases.The present study was aimed to evaluate in vitro and in… read more here.
Keywords: anti inflammatory; vitro vivo; vivo anti; activities mesua ... See more keywords
In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma
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DOI: 10.3389/fphar.2017.00373
Abstract: Malignant mesothelioma (MM) is a tumor arising from mesothelium. MM patients’ survival is poor. The polyphenol 4′,5,7,-trihydroxyflavone Apigenin (API) is a “multifunctional drug”. Several studies have demonstrated API anti-tumoral effects. However, little is known on… read more here.
Keywords: vitro vivo; vivo anti; anti tumoral; tumoral effects ... See more keywords
In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain
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DOI: 10.3390/antiox12020404
Abstract: There is growing evidence that Alzheimer’s disease (AD) can be prevented by reducing risk factors involved in its pathophysiology. Food-derived bioactive molecules can help in the prevention and reduction of the progression of AD. Honey,… read more here.
Keywords: honey; vivo; anti alzheimer; vivo anti ... See more keywords