Adaptation and optimization of a fluorescence-based assay for in vivo antimalarial drug screening
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology Research"
DOI: 10.1007/s00436-017-5477-z
Abstract: The in vivo efficacy of potential antimalarials is usually evaluated by direct microscopic determination of the parasitaemia of Plasmodium-infected mice on Giemsa-stained blood smears. This process is time-consuming, requires experienced technicians and is not automatable.… read more here.
Keywords: fluorescence; fluorescence based; antimalarial drug; based assay ... See more keywords
Repositioning miconazole nitrate for malaria: Formulation of sustained release nanostructured lipid carriers, structure characterization and in vivo antimalarial evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.102125
Abstract: Abstract It has been previously claimed that miconazole (MNZ) has activity against Plasmodium falciparum in vitro. Therefore, this study aims to evaluate the potential of MNZ as an alternative antimalarial agent. MNZ was entrapped in… read more here.
Keywords: lipid carriers; mnz; repositioning miconazole; vivo antimalarial ... See more keywords
In‐vitro and in‐vivo antimalarial activity of caffeic acid and some of its derivatives
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DOI: 10.1111/jphp.12982
Abstract: To explore the in‐vitro and in‐vivo antimalarial potential of caffeic acid and derivatives. read more here.
Keywords: caffeic acid; vitro vivo; antimalarial activity; acid derivatives ... See more keywords
In Vivo Antimalarial Effect of Yellow Root Stem (Fibraurea tinctoria Lour) on Plasmodium berghei
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DOI: 10.31838/srp.2020.6.60
Abstract: Background: Limitations of antimalarial chemotherapy demonstrate the importance of the discovery of new drugs. Indonesia has a high diversity of plants and some have been demonstrated to have activity as an antimalarial. Fibraurea tinctoria Lour… read more here.
Keywords: vivo antimalarial; plasmodium berghei; yellow root; stem ... See more keywords