Characterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry
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DOI: 10.1080/19420862.2018.1494487
Abstract: ABSTRACT Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) designed for the treatment of HER2-positive cancers. T-DM1 is composed of the humanized monoclonal antibody trastuzumab connected to a maytansine derivative cytotoxic drug, via a nonreducible… read more here.
Keywords: high resolution; trastuzumab emtansine; mass; resolution accurate ... See more keywords