In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.
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DOI: 10.1021/acs.analchem.2c00335
Abstract: Chemical crosslinking coupled with mass spectrometry (CXMS) has emerged as a powerful technique to obtain the dynamic conformations and interaction interfaces of protein complexes. Limited by the poor cell membrane permeability, chemical reactivity, and biocompatibility… read more here.
Keywords: vivo crosslinking; chemistry; membrane; crosslinker ... See more keywords