Recognizing CRISPR as the New Age Disease-Modifying Drug: Strategies to Bioengineer CRISPR/Cas for Direct in vivo Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202300077
Abstract: CRISPR has established itself as a frontier technology in genetic engineering. Researchers have successfully used the CRISPR/Cas system as precise gene editing tools and have further expanded their scope beyond both imaging and diagnostic applications.… read more here.
Keywords: cas; crispr cas; gene; vivo delivery ... See more keywords
In Vivo Delivery of Cassettes Encoding Anti-HBV Primary MicroRNAs Using an Ancestral Adeno-Associated Viral Vector.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0290-4_10
Abstract: Chronic hepatitis B, a liver disease resulting from persisting hepatitis B virus (HBV) infection, remains a global health challenge despite the availability of an effective vaccine. Various preclinical studies using adeno-associated viruses (AAVs) to deliver… read more here.
Keywords: anti hbv; encoding anti; cassettes encoding; delivery cassettes ... See more keywords
The cutting-edge technologies of siRNA delivery and their application in clinical trials
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-018-1069-4
Abstract: AbstractsiRNA therapeutics allows precise regulation of disease specific gene expression to treat various diseases. Although gene silencing approaches using siRNA therapeutics shows some promising results in the treatment of gene-related diseases, the practical applications has… read more here.
Keywords: sirna delivery; cutting edge; delivery; edge technologies ... See more keywords
Debugging the genetic code: non-viral in vivo delivery of therapeutic genome editing technologies.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biomedical engineering"
DOI: 10.1016/j.cobme.2018.08.002
Abstract: Efforts to precisely correct genomic mutations that underlie hereditary diseases for therapeutic benefit have advanced alongside the emergence and improvement of genome engineering technologies. These methods can be divided into two main classes: active nucleasebased… read more here.
Keywords: genome editing; non viral; delivery; vivo delivery ... See more keywords