Efficacy of Methionine-Restricted Diets on Cancers In Vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8796-2_7
Abstract: Methionine (MET) dependence is the elevated requirement of cancer cells for MET. Cancer cells are arrested when MET is restricted in late S/G2 phase of the cell cycle. MET dependence may be the only known… read more here.
Keywords: methionine; met dependence; human cancer; vivo efficacy ... See more keywords
Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104861
Abstract: Microsomal prostaglandin E2 synthase-1 (mPGES-1), 5-lipoxygenase (5-LO) and 5- lipoxygenase-activating protein (FLAP) are key for biosynthesis of proinflammatory lipid mediators and pharmacologically relevant drug targets. In the present study, we made an attempt to explore… read more here.
Keywords: scaffold; diarylisoxazol carboxylic; carboxylic acid; acid scaffold ... See more keywords
Clinical safety of lauric acid for cattle and its in vitro and in vivo efficacy against Rhipicephalus microplus.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary parasitology"
DOI: 10.1016/j.vetpar.2020.109095
Abstract: The aim of the present study was to test the in vitro acaricidal activity of saturated fatty acids (hexanoic, octanoic, decanoic, lauric, myristic, palmitic, octadecanoic, eicosanoic, docosanoic and tetracosanoic) against Rhipicephalus microplus and select a… read more here.
Keywords: rhipicephalus microplus; lauric myristic; safety; lauric acid ... See more keywords
In vitro and in vivo efficacy of diamidines against Trypanosoma equiperdum strains
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DOI: 10.1017/s0031182017002098
Abstract: Abstract Trypanosoma equiperdum is a protozoan parasite responsible for causing Dourine, a debilitating neglected veterinary disease, found worldwide affecting equids. It is the only pathogenic trypanosome species that does not require an invertebrate vector for… read more here.
Keywords: equiperdum strains; vitro vivo; trypanosoma equiperdum; vivo efficacy ... See more keywords
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01411
Abstract: A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During… read more here.
Keywords: disubstituted imidazopyridines; nsg mouse; plasmodium falciparum; vivo efficacy ... See more keywords
A Semisynthetic Kanglemycin Shows In Vivo Efficacy against High-Burden Rifampicin Resistant Pathogens
Sign Up to like & getrecommendations! Published in 2020 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.0c00223
Abstract: Semisynthetic rifamycin derivatives such as rifampicin (Rif) are first line treatments for tuberculosis and other bacterial infections. Historically, synthetic modifications made to the C-3/C-4 region of the rifamycin naphthalene core, like those seen in Rif,… read more here.
Keywords: semisynthetic kanglemycin; efficacy high; shows vivo; kanglemycin shows ... See more keywords
In Vivo Efficacy of WCK 5222 (Cefepime-Zidebactam) against Multidrug-Resistant Pseudomonas aeruginosa in the Neutropenic Murine Thigh Infection Model
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00233-19
Abstract: We describe the in vivo efficacy of human-simulated WCK 5222 (cefepime-zidebactam) exposure against multidrug-resistant Pseudomonas aeruginosa (meropenem MICs 8 to >256 μg/ml) in a neutropenic murine thigh infection model. WCK 5222 MICs ranged from 4 to… read more here.
Keywords: wck; cefepime zidebactam; vivo efficacy; 5222 cefepime ... See more keywords
T405, a New Penem, Exhibits In Vivo Efficacy against M. abscessus and Synergy with β-Lactams Imipenem and Cefditoren
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00536-22
Abstract: Mycobacteroides abscessus (Mab) is an emerging environmental microbe that causes chronic lung disease in patients with compromised lung function such as cystic fibrosis and bronchiectasis. It is intrinsically resistant to most antibiotics, therefore there are… read more here.
Keywords: mab; treat mab; disease; imipenem cefditoren ... See more keywords
Abstract 3993: In vivo efficacy of an anti-human IL11RA antibody in B-hIL11RA mice with APAP-induced liver damage
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3993
Abstract: Acetaminophen (N-acetyl-p-aminophenol; APAP) overdose is a common cause of drug-induced acute liver injury, thereby making APAP administration a frequently used experimental model due to its highly reproducible and dose-dependent hepatoxicity. APAP-induced liver injury (AILI) mouse… read more here.
Keywords: human il11ra; il11ra; anti human; vivo efficacy ... See more keywords
In vitro and in vivo efficacy and safety of tumor treating fields (TTFields) and sorafenib combination in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.551
Abstract: 551Background: Hepatocellular carcinoma (HCC) is a leading global cause of cancer-related mortality. Sorafenib (oral multikinase inhibitor) is approved in patients with advanced HCC, yet survival b... read more here.
Keywords: hepatocellular carcinoma; carcinoma; vitro vivo; efficacy safety ... See more keywords
Enhancement of In Vivo Efficacy and Oral Bioavailability of Aripiprazole with Solid Lipid Nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-017-0944-5
Abstract: Aripiprazole (ARP), a second-generation or atypical antipsychotic, is poorly soluble and undergoes extensive hepatic metabolism and P-glycoprotein efflux which lead to reduced in vivo efficacy and increased dose-related side effects. To enhance in vivo efficacy… read more here.
Keywords: vivo efficacy; bioavailability aripiprazole; solid lipid; lipid nanoparticles ... See more keywords