In vivo emergence of resistance to ceftazidime/avibactam through modification of chromosomal AmpC β-lactamase in Klebsiella aerogenes
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DOI: 10.1128/aac.01307-24
Abstract: ABSTRACT We describe the in vivo emergence of resistance to ceftazidime/avibactam via modification of AmpC in a clinical Klebsiella aerogenes isolate during therapy with this combination. Paired ceftazidime/avibactam-susceptible/resistant isolates were obtained before and during ceftazidime/avibactam… read more here.
Keywords: ceftazidime avibactam; klebsiella aerogenes; resistance ceftazidime; vivo emergence ... See more keywords
Cefiderocol: Systematic Review of Mechanisms of Resistance, Heteroresistance and In Vivo Emergence of Resistance
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DOI: 10.3390/antibiotics11060723
Abstract: Cefiderocol appears promising, as it can overcome most β-lactam resistance mechanisms (including β-lactamases, porin mutations, and efflux pumps). Resistance is uncommon according to large multinational cohorts, including against isolates resistant to carbapenems, ceftazidime/avibactam, ceftolozane/tazobactam, and… read more here.
Keywords: review; cefiderocol; resistance; emergence resistance ... See more keywords