Ex Vivo Expansion of Th2-Polarizing Immunotherapeutic iNKT Cells from Human Peripheral Blood.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1775-5_13
Abstract: iNKT cells, classified as innate lymphocytes with invariant TCRs, have been highlighted as a putative, "off-the-shelf" cellular immunotherapeutic strategy for the treatment of malignant and nonmalignant diseases. However, their paucity in human blood limits their… read more here.
Keywords: vivo expansion; inkt; expansion th2; blood ... See more keywords
Human Mesenchymal Stromal Cells Enhance the Stability of Umbilical Cord Blood Inducible Tregs during Ex Vivo Expansion Via Mitochondria Transfer
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.532
Abstract: Inducible regulatory T cells (iTreg) are a promising therapeutic cell source that exhibit Foxp3 expression and suppressive functions similar to natural regulatory T cells. Nonetheless, their clinical potential is limited by the instability of Foxp3… read more here.
Keywords: blood; stability; stromal cells; vivo expansion ... See more keywords
Review of the Small-Molecule Nicotinamide for Ex Vivo Expansion of Umbilical Cord Blood.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2019.11.006
Abstract: Umbilical cord blood transplant (UCB) is an alternative graft source for patients lacking an HLA-matched donor; however, delayed engraftment times have historically resulted in transplant-related mortality (TRM) due to complications such as infections and ineffective… read more here.
Keywords: vivo expansion; cord blood; expansion; umbilical cord ... See more keywords
Reduced neuroprotective potential of the mesenchymal stromal cell secretome with ex vivo expansion, age and progressive multiple sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2017.08.007
Abstract: Background Clinical trials using ex vivo expansion of autologous mesenchymal stromal cells (MSCs) are in progress for several neurological diseases including multiple sclerosis (MS). Given that environment alters MSC function, we examined whether in vitro… read more here.
Keywords: vivo expansion; mesenchymal stromal; expansion; age ... See more keywords
Gamma irradiated human platelet lysate as a serum substitute for ex vivo expansion of immune cells
Sign Up to like & getrecommendations! Published in 2020 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2020.03.272
Abstract: Background & Aim Adoptive immunotherapy is emerged as one of the leading treatments in cancer. The clinical applications require ex vivo expansion of lymphocytes to therapeutic doses in a timely manner under strict cGMP compliance.… read more here.
Keywords: vivo expansion; expansion; hpl; human platelet ... See more keywords
Use of Splenocytes as Stimulators for the Ex Vivo Expansion of T Regulatory Cells using Costimulatory Blockade for Adoptive Transfer to Solid Organ Transplant Recipients
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/01.tp.0000542997.16512.ef
Abstract: Introduction Adoptive transfer of ex vivo generated alloantigen-specific regulatory T cells (Treg) by using CD28/B7 co-stimulatory blockade (CSB) to induce transplant tolerance and minimize the use of immunosuppressants has been successfully used in Phase I/II… read more here.
Keywords: vivo expansion; expansion; regulatory cells; cells using ... See more keywords
Update on preclinical and clinical efforts on ex-vivo expansion of hematopoietic stem and progenitor cells
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000714
Abstract: Purpose of review Ex-vivo expansion of hematopoietic stem cells (HSCs) is one potential approach to enhance the clinical efficacy of hematopoietic cell transplantation-based therapy for malignant and nonmalignant blood diseases. Here, we discuss the major… read more here.
Keywords: preclinical clinical; hematopoietic stem; expansion hematopoietic; progenitor cells ... See more keywords
A soluble activator that favors the ex vivo expansion of CD8+CD27+ T cells
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.141293
Abstract: Adoptive cell therapy involves the infusion of tumor-reactive T cells into patients with cancer to provide antitumor immunity. The ex vivo expansion and differentiation of such T cells are key parameters that affect their therapeutic… read more here.
Keywords: vivo expansion; expansion; cd28; cell ... See more keywords
Influence of Culture Conditions on Ex Vivo Expansion of T Lymphocytes and Their Function for Therapy: Current Insights and Open Questions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.886637
Abstract: Ex vivo expansion of T lymphocytes is a central process in the generation of cellular therapies targeted at tumors and other disease-relevant structures, which currently cannot be reached by established pharmaceuticals. The influence of culture… read more here.
Keywords: culture; culture conditions; influence culture; expansion lymphocytes ... See more keywords
The magic of small-molecule drugs during ex vivo expansion in adoptive cell therapy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1154566
Abstract: In the past decades, advances in the use of adoptive cellular therapy to treat cancer have led to unprecedented responses in patients with relapsed/refractory or late-stage malignancies. However, cellular exhaustion and senescence limit the efficacy… read more here.
Keywords: small molecule; cell; therapy; expansion ... See more keywords
Efficient ex vivo expansion of conserved element vaccine-specific CD8+ T-cells from SHIV-infected, ART-suppressed nonhuman primates
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1188018
Abstract: HIV-specific T cells are necessary for control of HIV-1 replication but are largely insufficient for viral clearance. This is due in part to these cells’ recognition of immunodominant but variable regions of the virus, which… read more here.
Keywords: efficient vivo; hiv specific; specific cells; vivo expansion ... See more keywords