Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22521
Abstract: Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Traditional genotoxicity assays (i.e., mutagenicity, clastogenicity, and aneugenicity) have been limited to dichotomous hazard classification, while other toxicity endpoints are assessed through… read more here.
Keywords: genotoxicity data; genotoxicity; vitro vivo; vivo extrapolation ... See more keywords
In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.04.045
Abstract: Evaluation of drug-drug interaction (DDI) risk is vital to establish benefit-risk profiles of investigational new drugs during drug development. In vitro experiments are routinely conducted as an important first step to assess metabolism- and transporter-mediated DDI… read more here.
Keywords: transporter mediated; vitro vivo; drug; vivo extrapolation ... See more keywords
Examining Uncertainty in in Vitro-in Vivo Extrapolation Applied in Fish Bioconcentration Models.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental science & technology"
DOI: 10.1021/acs.est.0c01492
Abstract: In vitro biotransformation rates were determined for 30 chemicals, mostly fragrance ingredients, using trout liver S9 fractions (RT-S9) and incorporated into in vitro-in vivo extrapolation (IVIVE) models to predict bioconcentration factors (BCFs). Predicted BCFs were… read more here.
Keywords: bcfs; bioconcentration; vitro vivo; biotransformation ... See more keywords
Validation of Methods for in Vitro-in Vivo Extrapolation Using Hepatic Clearance Measurements in Isolated Perfused Fish Livers.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c02656
Abstract: In vitro biotransformation assays using hepatocytes or liver subcellular fractions, combined with in vitro-in vivo extrapolation (IVIVE) models, have been proposed as an alternative to live fish bioconcentration studies. The uncertainty associated with IVIVE approaches… read more here.
Keywords: clearance; vitro vivo; hepatic clearance; vivo extrapolation ... See more keywords
Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy020
Abstract: Prioritizing the risk posed by thousands of chemicals potentially present in the environment requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable. Relatively high throughput, in vitro TK (HTTK) assays and in vitro-to-in… read more here.
Keywords: non pharmaceutical; vitro vivo; vivo; bioavailability ... See more keywords
Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance
Sign Up to like & getrecommendations! Published in 2020 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.120.000131
Abstract: The use of in vitro in vivo extrapolation (IVIVE) from human hepatocyte (HH) and human liver microsome (HLM) stability assays is a widely accepted predictive methodology for human metabolic clearance (CLmet). However, a systematic underprediction… read more here.
Keywords: vitro vivo; hlm; clearance; vivo extrapolation ... See more keywords
Quantitative in Vitro to in Vivo Extrapolation (QIVIVE) for Predicting Reduced Anogenital Distance Produced by Anti-Androgenic Pesticides in a Rodent Model for Male Reproductive Disorders
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Health Perspectives"
DOI: 10.1289/ehp6774
Abstract: Background: Many pesticides can antagonize the androgen receptor (AR) or inhibit androgen synthesis in vitro but their potential to cause reproductive toxicity related to disruption of androgen action during fetal life is difficult to predict.… read more here.
Keywords: vitro vivo; vivo; model; quantitative vitro ... See more keywords