Alpha-ketoglutarate mediated hepatoprotection against alcohol induced toxicity: in vivo functional observation studies in Sprague Dawley rats using gamma scintigraphy
Sign Up to like & getrecommendations! Published in 2019 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2018.1559183
Abstract: Abstract Alcohol is the most abused psychoactive substance and known hepatotoxicant. Present study elucidates possible therapeutic effect of oral alpha-ketoglutarate (AKG) supplementation against alcohol induced hepatic dysfunction, using biochemical, histopathological and most importantly, in vivo… read more here.
Keywords: alpha ketoglutarate; scintigraphy; group; alcohol induced ... See more keywords
EPCO-11. IN VIVO FUNCTIONAL GENOMIC SCREEN IDENTIFIES WISP1 AS AN OVEREXPRESSED DRIVER OF GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.290
Abstract: There is a tremendous need to identify new genetic drivers of glioblastoma which can serve as potential therapeutic targets. In order to find new drivers, we leveraged genomic datasets to conduct a context specific in… read more here.
Keywords: driver; functional genomic; vivo functional; overexpressed driver ... See more keywords
In Vivo Functional Characterization of EGFR Variants Identifies Novel Drivers of Glioblastoma.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac215
Abstract: BACKGROUND Glioblastoma is the most common and aggressive primary brain tumor. Large scale sequencing initiatives have cataloged its mutational landscape in hopes of elucidating mechanisms driving this deadly disease. However, a major bottleneck in harnessing… read more here.
Keywords: functional characterization; variants identifies; vivo functional; egfr variants ... See more keywords
Abstract 274: Mitochondrial Translation Machinery Defects Causes Cardiomyopathy and i n vivo Functional Screening of Therapeutic Targets
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.274
Abstract: More than 95% of ATP consumed in the heart is derived from oxidative phosphorylation (OxPhos) in the mitochondria. Besides over a thousand proteins encoded by nuclear DNA, mitochondrial gene expression machinery generates 13 proteins for… read more here.
Keywords: heart; machinery; mrps5 deficient; vivo functional ... See more keywords
In vivo Functional Characterization of Hydrophilic X2 Modules in the Cellulosomal Scaffolding Protein
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.861549
Abstract: As part of free cellulases or scaffolding proteins in cellulosomes, the hydrophilic non-catalytic X2 module is widely distributed in cellulolytic Clostridia or other Firmicutes bacteria. Previous biochemical studies suggest that X2 modules might increase the… read more here.
Keywords: modules cellulosomal; hydrophilic modules; cellulosomal scaffolding; functional characterization ... See more keywords
In Vitro and In Vivo Functional Characterization of Essence of Chicken as An Ergogenic Aid
Sign Up to like & getrecommendations! Published in 2018 at "Nutrients"
DOI: 10.3390/nu10121943
Abstract: Essence of chicken is a popular Asian nutritional supplement that is often taken to improve metabolism and general health. Although used as a traditional remedy for combating fatigue and general health, there has been few… read more here.
Keywords: vitro vivo; functional characterization; essence; vivo functional ... See more keywords
In vivo functional diversity of midbrain dopamine neurons within identified axonal projections
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.48408
Abstract: Functional diversity of midbrain dopamine (DA) neurons ranges across multiple scales, from differences in intrinsic properties and connectivity to selective task engagement in behaving animals. Distinct in vitro biophysical features of DA neurons have been… read more here.
Keywords: midbrain dopamine; dopamine neurons; functional diversity; diversity midbrain ... See more keywords