Prediction of in vivo genotoxicity of lasiocarpine and riddelliine in rat liver using a combined in vitro-physiologically based kinetic modelling-facilitated reverse dosimetry approach
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02515-5
Abstract: Pyrrolizidine alkaloids (PAs) are naturally occurring genotoxic compounds, and PA-containing plants can pose a risk to humans through contaminated food sources and herbal products. Upon metabolic activation, PAs can form DNA adducts, DNA and protein… read more here.
Keywords: vivo genotoxicity; genotoxicity; reverse dosimetry; rat ... See more keywords
A review of mammalian in vivo genotoxicity of hexavalent chromium: implications for oral carcinogenicity risk assessment
Sign Up to like & getrecommendations! Published in 2022 at "Critical Reviews in Toxicology"
DOI: 10.1080/10408444.2021.2000934
Abstract: Abstract Assessment of genotoxicity is a critical component of mode of action (MOA) analysis and carcinogen risk assessment due to its influence on quantitative risk extrapolation approaches. To date, clear guidance and expert consensus on… read more here.
Keywords: risk; vivo genotoxicity; risk assessment; genotoxicity ... See more keywords