GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07644-6
Abstract: Mutant KRas is a significant driver of human oncogenesis and confers resistance to therapy, underscoring the need to develop approaches that disable mutant KRas-driven tumors. Because targeting KRas directly has proven difficult, identifying vulnerabilities specific… read more here.
Keywords: vivo growth; dependent tumors; mutant kras; kras dependent ... See more keywords
Abstract 3098: Promotion of in vivo growth of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma by miR-BARTs
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3098
Abstract: Epstein-Barr virus (EBV) infection is nearly 100% associated with undifferentiated nasopharyngeal carcinoma (NPC). However, EBV episomes are rapidly lost under in vitro culturing if there is no selective advantage to their retention. The persistence of… read more here.
Keywords: ebv; epstein barr; vivo growth; mir barts ... See more keywords
Combining Nelfinavir With Chloroquine Inhibits In Vivo Growth of Human Lung Cancer Xenograft Tumors
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DOI: 10.21873/invivo.12241
Abstract: Background/Aim: Nelfinavir is a human immunodeficiency virus protease inhibitor that is currently being repositioned as an anticancer drug. Chloroquine, an anti-malarial lysosomotropic drug, inhibits autophagy. It has been reported that the combination of nelfinavir and… read more here.
Keywords: nelfinavir chloroquine; vivo growth; xenograft; chloroquine ... See more keywords
Mycobacterium leprae Transcriptome During In Vivo Growth and Ex Vivo Stationary Phases
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DOI: 10.3389/fcimb.2021.817221
Abstract: Mycobacterium leprae, the causative agent of leprosy, is an obligate intracellular pathogen primarily residing within host macrophages and Schwann cells. Whole genome sequencing predicts a highly degraded genome with approximately one third of the coding… read more here.
Keywords: growth vivo; compared mfp5; growth; mycobacterium leprae ... See more keywords