In Vivo Identification of Adducts from the New Hypoxia-Activated Prodrug CP-506 Using DNA Adductomics.
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DOI: 10.1021/acs.chemrestox.1c00329
Abstract: Many chemotherapeutic drugs exert their cytotoxicity through the formation of DNA modifications (adducts), which interfere with DNA replication, an overactive process in rapidly dividing cancer cells. Side effects from the therapy are common, however, because… read more here.
Keywords: dna; hypoxia activated; vivo identification; dna adducts ... See more keywords